含高良姜的金纳米颗粒:乳腺癌中抗血管生成特性的分子机制。

IF 1.6 Q4 ONCOLOGY International Journal of Breast Cancer Pub Date : 2023-01-01 DOI:10.1155/2023/3251211
Malik H Qaddoori, Hanady S Al-Shmgani
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引用次数: 8

摘要

血管生成在正常生理过程中对组织以及包括癌症在内的许多疾病中都很重要。耐药是抗血管生成治疗的最大困难之一。由于植物化学抗癌药物具有较低的细胞毒性和较强的药理优势,因此与化学化疗药物相比具有许多优势。在本研究中,评估了AuNPs、AuNPs- gal和游离高良姜素作为抗血管生成剂的有效性。在MCF-7和MDA-MB-231人乳腺癌细胞系中,使用了不同的物理化学和分子方法,包括表征、细胞毒性、划伤愈合试验和VEGF和ERKI的基因表达。MTT试验结果显示细胞生长呈时间和剂量依赖性;此外,与单独治疗相比,还显示了协同效应。CAM实验结果表明高良姜金纳米颗粒能够抑制鸡胚血管生成。此外,记录VEGF和ERKI基因表达的变化。综上所述,高良姜素结合的金纳米颗粒可能是一种很有前途的抗血管生成补充药物,用于乳腺癌治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Galangin-Loaded Gold Nanoparticles: Molecular Mechanisms of Antiangiogenesis Properties in Breast Cancer.

Angiogenesis is important for tissue during normal physiological processes as well as in a number of diseases, including cancer. Drug resistance is one of the largest difficulties to antiangiogenesis therapy. Due to their lower cytotoxicity and stronger pharmacological advantage, phytochemical anticancer medications have a number of advantages over chemical chemotherapeutic drugs. In the current study, the effectiveness of AuNPs, AuNPs-GAL, and free galangin as an antiangiogenesis agent was evaluated. Different physicochemical and molecular approaches have been used including the characterization, cytotoxicity, scratch wound healing assay, and gene expression of VEGF and ERKI in MCF-7 and MDA-MB-231 human breast cancer cell line. Results obtained from MTT assay show cell growth reduction in a time- and dose-dependent aspect; also, in comparison to individual treatment, a synergistic impact was indicated. CAM assay results demonstrated galangin-gold nanoparticle capacity to suppress angiogenesis in chick embryo. Additionally, altering VEGF and ERKI gene expression was recorded. Taken together, all the results can conclude that galangin-conjugated gold nanoparticles can be a promising antiangiogenesis supplemental drug in breast cancer treatment.

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来源期刊
CiteScore
3.40
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: International Journal of Breast Cancer is a peer-reviewed, Open Access journal that provides a forum for scientists, clinicians, and health care professionals working in breast cancer research and management. The journal publishes original research articles, review articles, and clinical studies related to molecular pathology, genomics, genetic predisposition, screening and diagnosis, disease markers, drug sensitivity and resistance, as well as novel therapies, with a specific focus on molecular targeted agents and immune therapies.
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