Jonas F Schiemer, Karen Stumm, Karin H Somerlik-Fuchs, Klaus-Peter Hoffmann, Roman Ruff, Hauke Lang, Stefan Farkas, Jan Baumgart, Werner Kneist
{"title":"放置Theranos设备前的腹腔镜肌电图和胃肠道电刺激。","authors":"Jonas F Schiemer, Karen Stumm, Karin H Somerlik-Fuchs, Klaus-Peter Hoffmann, Roman Ruff, Hauke Lang, Stefan Farkas, Jan Baumgart, Werner Kneist","doi":"10.1177/15533506221147718","DOIUrl":null,"url":null,"abstract":"<p><strong>Need: </strong>Electrical stimulation (ES) is a promising therapy for multisegmental gastrointestinal (GI) motility disorders such as gastroparesis with slow-transit constipation or chronic intestinal pseudo-obstruction. Wireless communicating GI devices for smart sensing and ES-based motility modulation will soon be available. Before placement, a potential benefit for each GI segment must be intraoperatively assessed.</p><p><strong>Technical solution: </strong>A minimally invasive multisegmental electromyography (EMG) analysis with ES of the GI tract is required.</p><p><strong>Proof of concept: </strong>Two porcine experiments were performed with a laparoscopic setup. Multiple hook-needle electrodes were subserosally applied in the stomach, duodenum, jejunum, ileum, and colon. EMG signals were acquired for computer-assisted motility analysis. Gastric ES, duodenal ES, jejunal ES, ileal ES, and colonic ES were applied.</p><p><strong>Next steps: </strong>Further technological and rapid regulatory solutions are desired to initialize a clinical trial of the next generation devices in the near future.</p><p><strong>Conclusion: </strong>We demonstrate a laparoscopic strategy with EMG analysis and ES of multiple GI segments. Thus, GI function may be evaluated before theranostic devices are placed. Extended GI resection or organ transplantation may be delayed or even avoided in affected patients.</p>","PeriodicalId":22095,"journal":{"name":"Surgical Innovation","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Laparoscopic Electromyography and Electrostimulation of the Gastrointestinal Tract Before Placement of Theranostic Devices.\",\"authors\":\"Jonas F Schiemer, Karen Stumm, Karin H Somerlik-Fuchs, Klaus-Peter Hoffmann, Roman Ruff, Hauke Lang, Stefan Farkas, Jan Baumgart, Werner Kneist\",\"doi\":\"10.1177/15533506221147718\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Need: </strong>Electrical stimulation (ES) is a promising therapy for multisegmental gastrointestinal (GI) motility disorders such as gastroparesis with slow-transit constipation or chronic intestinal pseudo-obstruction. Wireless communicating GI devices for smart sensing and ES-based motility modulation will soon be available. Before placement, a potential benefit for each GI segment must be intraoperatively assessed.</p><p><strong>Technical solution: </strong>A minimally invasive multisegmental electromyography (EMG) analysis with ES of the GI tract is required.</p><p><strong>Proof of concept: </strong>Two porcine experiments were performed with a laparoscopic setup. Multiple hook-needle electrodes were subserosally applied in the stomach, duodenum, jejunum, ileum, and colon. EMG signals were acquired for computer-assisted motility analysis. Gastric ES, duodenal ES, jejunal ES, ileal ES, and colonic ES were applied.</p><p><strong>Next steps: </strong>Further technological and rapid regulatory solutions are desired to initialize a clinical trial of the next generation devices in the near future.</p><p><strong>Conclusion: </strong>We demonstrate a laparoscopic strategy with EMG analysis and ES of multiple GI segments. Thus, GI function may be evaluated before theranostic devices are placed. Extended GI resection or organ transplantation may be delayed or even avoided in affected patients.</p>\",\"PeriodicalId\":22095,\"journal\":{\"name\":\"Surgical Innovation\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2023-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Surgical Innovation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15533506221147718\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/12/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"SURGERY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgical Innovation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15533506221147718","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/12/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}
Laparoscopic Electromyography and Electrostimulation of the Gastrointestinal Tract Before Placement of Theranostic Devices.
Need: Electrical stimulation (ES) is a promising therapy for multisegmental gastrointestinal (GI) motility disorders such as gastroparesis with slow-transit constipation or chronic intestinal pseudo-obstruction. Wireless communicating GI devices for smart sensing and ES-based motility modulation will soon be available. Before placement, a potential benefit for each GI segment must be intraoperatively assessed.
Technical solution: A minimally invasive multisegmental electromyography (EMG) analysis with ES of the GI tract is required.
Proof of concept: Two porcine experiments were performed with a laparoscopic setup. Multiple hook-needle electrodes were subserosally applied in the stomach, duodenum, jejunum, ileum, and colon. EMG signals were acquired for computer-assisted motility analysis. Gastric ES, duodenal ES, jejunal ES, ileal ES, and colonic ES were applied.
Next steps: Further technological and rapid regulatory solutions are desired to initialize a clinical trial of the next generation devices in the near future.
Conclusion: We demonstrate a laparoscopic strategy with EMG analysis and ES of multiple GI segments. Thus, GI function may be evaluated before theranostic devices are placed. Extended GI resection or organ transplantation may be delayed or even avoided in affected patients.
期刊介绍:
Surgical Innovation (SRI) is a peer-reviewed bi-monthly journal focusing on minimally invasive surgical techniques, new instruments such as laparoscopes and endoscopes, and new technologies. SRI prepares surgeons to think and work in "the operating room of the future" through learning new techniques, understanding and adapting to new technologies, maintaining surgical competencies, and applying surgical outcomes data to their practices. This journal is a member of the Committee on Publication Ethics (COPE).