缺乏功能性脊髓灰质炎病毒受体的麻疹病毒受体表达Vero细胞的建立

IF 1.9 4区医学 Q4 IMMUNOLOGY Microbiology and Immunology Pub Date : 2022-12-23 DOI:10.1111/1348-0421.13047

Kenji Someya, Yuko Okemoto-Nakamura, Takako Kurata, Daiki Kanbayashi, Noriko Saito, Masae Itamochi, Noriyuki Otsuki, Kentaro Hanada, Makoto Takeda

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引用次数: 0

摘要

全球正在努力消除麻疹和风疹，积极监测病毒是实现这一目标的关键。此外，世界卫生组织宣布了处理脊髓灰质炎病毒(PV)潜在传染性材料的指导方针，以尽量减少PV重新引入的风险并实现PV根除。为了支持全球努力，我们建立了新的pv不敏感细胞系，可用于分离麻疹病毒(MeV)和风疹病毒(RuV) (Vero ΔPVR1/2 hSLAM+)。在细胞系中，MeV和RuV可以有效地复制，与PV复制无关。

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Establishment of measles virus receptor-expressing Vero cells lacking functional poliovirus receptors

Global efforts are underway to eliminate measles and rubella, and active viral surveillance is the key to achieving this goal. In addition, the World Health Organization announced guidelines for handling materials potentially infectious for poliovirus (PV) to minimize the risk of PV reintroduction and to achieve PV eradication. To support global efforts, we established new PV-non-susceptible cell lines that are useful for the isolation of measles virus (MeV) and rubella virus (RuV) (Vero ΔPVR1/2 hSLAM+). In the cell lines, MeV and RuV replicated efficiently, with no concern regarding PV replication.

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来源期刊

Microbiology and Immunology 医学-免疫学

CiteScore

5.20

自引率

3.80%

发文量

审稿时长

1 months

期刊介绍： Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.