模拟应用尖刺滑石粉导致石棉暴露的评估。

IF 2 4区 医学 Q4 TOXICOLOGY Inhalation Toxicology Pub Date : 2022-01-01 DOI:10.1080/08958378.2022.2132324
Eric W Miller, Benjamin Roberts, Kara Keeton, Andrew Monnot, Taylor Tarpey, Nicole Zoghby, Alan Segrave, Jennifer S Pierce
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引用次数: 1

摘要

本研究的特点是空气中石棉暴露造成的成人应用化妆品滑石身体粉与已知浓度的透闪石。原料滑石矿分别加入0.005%和0.1%的石棉质或非石棉质透闪石。在16个模拟事件中收集个人样本,包括喷雾器和摇床的应用以及相关的清理活动。在滑石粉中掺入石棉和非石棉透闪石的模拟中,空气纤维水平(PCM)没有显著差异(p = 0.6104)。对于添加了0.005%石棉透闪石的滑石粉的应用和清理,24个样品中有2个(8.3%)高于TEM的下限(0.003 f/cc)。当滑石中添加0.1%的石棉透闪石时,24个滑石中有21个(87.5%)高于TEM的LOD。在前15分钟采集的样品中,相应的PCME石棉平均浓度为抽吸和摇床0.016 f/cc,第二个15分钟内抽吸和摇床分别为0.002 f/cc和0.004 f/cc,整个30分钟内抽吸和摇床分别为0.005 f/cc和0.013 f/cc。使用含0.1%石棉透闪石的滑石粉进行清理后收集的样品的PCME平均浓度为:喷雾剂使用后15分钟收集的样品为0.003 f/cc,振动筛使用后15分钟收集的样品为0.005 f/cc,其余清理样品为0 f/cc。使用EPA的暴露因子,我们确定了产品使用可能导致的累积石棉纤维暴露范围,假设石棉透闪石的含量为0.1%。
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Evaluation of asbestos exposure resulting from simulated application of spiked talcum powders.

This study characterizes airborne asbestos exposures resulting from the adult application of cosmetic talc body powders spiked with known concentrations of tremolite. Raw talc ores were spiked with 0.005% and 0.1% asbestiform or non-asbestiform tremolite. Personal samples were collected during 16 simulated events, including puff and shaker application and associated clean-up activities. Airborne fiber levels (PCM) were not significantly different for simulations involving talc spiked with asbestiform and non-asbestiform tremolite (p = 0.6104). For application and clean-up of talc spiked with 0.005% asbestiform tremolite, 2 of 24 (8.3%) samples were above the LOD for TEM (0.003 f/cc). For application of talc spiked with 0.1% asbestiform tremolite, 21 of 24 (87.5%) were above the LOD for TEM. The corresponding mean PCME asbestos concentrations were 0.016 f/cc for puff and shaker for samples collected in the first 15 min, 0.002 f/cc for puff and 0.004 f/cc for shaker in the second 15 min, and 0.005 f/cc for puff and 0.013 f/cc for shaker for the full 30 min. Mean PCME concentrations for samples collected during clean-up following application of talc spiked with 0.1% asbestiform tremolite were 0.003 f/cc for samples collected in the first 15 min following puff application, 0.005 f/cc for samples collected in the second 15 min following shaker application, and 0 f/cc for the remaining clean-up samples. Using the EPA's exposure factors, we determined the range of cumulative asbestiform fiber exposures that would result from product use, assuming asbestiform tremolite was present at 0.1%.

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来源期刊
Inhalation Toxicology
Inhalation Toxicology 医学-毒理学
CiteScore
4.10
自引率
4.80%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Inhalation Toxicology is a peer-reviewed publication providing a key forum for the latest accomplishments and advancements in concepts, approaches, and procedures presently being used to evaluate the health risk associated with airborne chemicals. The journal publishes original research, reviews, symposia, and workshop topics involving the respiratory system’s functions in health and disease, the pathogenesis and mechanism of injury, the extrapolation of animal data to humans, the effects of inhaled substances on extra-pulmonary systems, as well as reliable and innovative models for predicting human disease.
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