{"title":"去细胞异体移植物作为重建大下牙槽神经缺损的替代方法:系统综述。","authors":"G Matus, J-P Aravena, D Mariño, S-E Niklander","doi":"10.4317/medoral.25647","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Inferior alveolar nerve (IAN) injuries are a clinical problem with devastating consequences, causing temporary or permanent paresthesia, significantly affecting the patient's quality of life. Despite morbidity, side effects and controversy regarding its results, autologous nerve grafting is still the main treatment for these type of lesions. However, due to advances in knowledge about nerve damage and with the aim of preventing the described problems of autografts, new treatment alternatives based on decellularized allografts have emerged. The aim of this systematic review was to evaluate the reported efficacy of decellularized allografts for the treatment of IAN damage.</p><p><strong>Material and methods: </strong>We performed a systematic search in Pubmed, Scopus and Web of Science databases following the PRISMA guidelines. Cohort studies, randomized or non-randomized clinical studies, prospective or retrospective studies, without age limits and language restriction that included human subjects who received decellularized allograft as treatment for IAN damage were included.</p><p><strong>Results: </strong>Six articles met the inclusion criteria and were included for data analysis. In all 6 articles, resolution of IAN damage was observed in more than 85% of patients after a 12-month follow-up period, and in 2 of them, complete resolution was observed in 100% of their patients at longer follow-ups.</p><p><strong>Conclusions: </strong>Decellularized allograft appears to be a promising alternative to resolve IAN lesions, without requiring a nerve autograft procedure. However, more randomized clinical trials are needed to validate adequate treatment modalities with decellularized allografts.</p>","PeriodicalId":18351,"journal":{"name":"Medicina oral, patologia oral y cirugia bucal","volume":"28 2","pages":"e183-e190"},"PeriodicalIF":2.2000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985938/pdf/","citationCount":"1","resultStr":"{\"title\":\"Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects: a systematic review.\",\"authors\":\"G Matus, J-P Aravena, D Mariño, S-E Niklander\",\"doi\":\"10.4317/medoral.25647\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Inferior alveolar nerve (IAN) injuries are a clinical problem with devastating consequences, causing temporary or permanent paresthesia, significantly affecting the patient's quality of life. Despite morbidity, side effects and controversy regarding its results, autologous nerve grafting is still the main treatment for these type of lesions. However, due to advances in knowledge about nerve damage and with the aim of preventing the described problems of autografts, new treatment alternatives based on decellularized allografts have emerged. The aim of this systematic review was to evaluate the reported efficacy of decellularized allografts for the treatment of IAN damage.</p><p><strong>Material and methods: </strong>We performed a systematic search in Pubmed, Scopus and Web of Science databases following the PRISMA guidelines. Cohort studies, randomized or non-randomized clinical studies, prospective or retrospective studies, without age limits and language restriction that included human subjects who received decellularized allograft as treatment for IAN damage were included.</p><p><strong>Results: </strong>Six articles met the inclusion criteria and were included for data analysis. In all 6 articles, resolution of IAN damage was observed in more than 85% of patients after a 12-month follow-up period, and in 2 of them, complete resolution was observed in 100% of their patients at longer follow-ups.</p><p><strong>Conclusions: </strong>Decellularized allograft appears to be a promising alternative to resolve IAN lesions, without requiring a nerve autograft procedure. 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引用次数: 1
摘要
背景:下肺泡神经(IAN)损伤是一个具有破坏性后果的临床问题,可引起暂时或永久性的感觉异常,严重影响患者的生活质量。尽管发病率、副作用和对其结果的争议,自体神经移植仍然是这类病变的主要治疗方法。然而,由于神经损伤知识的进步和防止自体移植物所描述的问题的目的,基于脱细胞异体移植物的新治疗方案已经出现。本系统综述的目的是评估报道的去细胞异体移植物治疗IAN损伤的疗效。材料和方法:我们按照PRISMA指南在Pubmed、Scopus和Web of Science数据库中进行了系统的检索。队列研究,随机或非随机临床研究,前瞻性或回顾性研究,没有年龄限制和语言限制,包括接受去细胞异体移植作为治疗IAN损伤的人类受试者。结果:6篇文章符合纳入标准,被纳入数据分析。在所有6篇文章中,超过85%的患者在12个月的随访期后观察到IAN损伤的消退,其中2篇文章在更长时间的随访中观察到100%的患者完全消退。结论:去细胞异体移植物似乎是解决IAN病变的一个有希望的选择,不需要神经自体移植手术。然而,需要更多的随机临床试验来验证脱细胞同种异体移植的适当治疗方式。
Decellularized allografts as an alternative for reconstruction of large inferior alveolar nerve defects: a systematic review.
Background: Inferior alveolar nerve (IAN) injuries are a clinical problem with devastating consequences, causing temporary or permanent paresthesia, significantly affecting the patient's quality of life. Despite morbidity, side effects and controversy regarding its results, autologous nerve grafting is still the main treatment for these type of lesions. However, due to advances in knowledge about nerve damage and with the aim of preventing the described problems of autografts, new treatment alternatives based on decellularized allografts have emerged. The aim of this systematic review was to evaluate the reported efficacy of decellularized allografts for the treatment of IAN damage.
Material and methods: We performed a systematic search in Pubmed, Scopus and Web of Science databases following the PRISMA guidelines. Cohort studies, randomized or non-randomized clinical studies, prospective or retrospective studies, without age limits and language restriction that included human subjects who received decellularized allograft as treatment for IAN damage were included.
Results: Six articles met the inclusion criteria and were included for data analysis. In all 6 articles, resolution of IAN damage was observed in more than 85% of patients after a 12-month follow-up period, and in 2 of them, complete resolution was observed in 100% of their patients at longer follow-ups.
Conclusions: Decellularized allograft appears to be a promising alternative to resolve IAN lesions, without requiring a nerve autograft procedure. However, more randomized clinical trials are needed to validate adequate treatment modalities with decellularized allografts.
期刊介绍:
1. Oral Medicine and Pathology:
Clinicopathological as well as medical or surgical management aspects of
diseases affecting oral mucosa, salivary glands, maxillary bones, as well as
orofacial neurological disorders, and systemic conditions with an impact on
the oral cavity.
2. Oral Surgery:
Surgical management aspects of diseases affecting oral mucosa, salivary glands,
maxillary bones, teeth, implants, oral surgical procedures. Surgical management
of diseases affecting head and neck areas.
3. Medically compromised patients in Dentistry:
Articles discussing medical problems in Odontology will also be included, with
a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients.
4. Implantology
5. Periodontology