农药对过氧化物酶体增殖物激活受体的影响及其与肥胖和糖尿病的关系

IF 3.5 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL PPAR Research Pub Date : 2023-01-01 DOI:10.1155/2023/1743289

J Hernández-Valdez, A Velázquez-Zepeda, J C Sánchez-Meza

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引用次数: 1

摘要

肥胖和糖尿病被认为是21世纪最重要的疾病。最近，许多流行病学研究已经将农药暴露与肥胖和2型糖尿病的发展联系起来。通过研究农药与控制脂质和碳水化合物代谢的主要核受体家族之一:过氧化物酶体增殖体激活受体(PPARs)、PPARα、PPARβ/δ和PPARγ之间的关系，探讨农药在这些疾病发生中的作用及其可能的影响;这是可能通过在硅，体外和体内的分析。本文旨在揭示农药对ppar的影响及其在能量代谢变化中的作用，这些变化导致肥胖和2型糖尿病的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Effect of Pesticides on Peroxisome Proliferator-Activated Receptors (PPARs) and Their Association with Obesity and Diabetes.

Obesity and diabetes mellitus are considered the most important diseases of the XXI century. Recently, many epidemiological studies have linked exposure to pesticides to the development of obesity and type 2 diabetes mellitus. The role of pesticides and their possible influence on the development of these diseases was investigated by examining the relationship between these compounds and one of the major nuclear receptor families controlling lipid and carbohydrate metabolism: the peroxisome proliferator-activated receptors (PPARs), PPARα, PPARβ/δ, and PPARγ; this was possible through in silico, in vitro, and in vivo assays. The present review aims to show the effect of pesticides on PPARs and their contribution to the changes in energy metabolism that enable the development of obesity and type 2 diabetes mellitus.

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来源期刊

PPAR Research MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

6.20

自引率

3.40%

发文量

审稿时长

12 months

期刊介绍： PPAR Research is a peer-reviewed, Open Access journal that publishes original research and review articles on advances in basic research focusing on mechanisms involved in the activation of peroxisome proliferator-activated receptors (PPARs), as well as their role in the regulation of cellular differentiation, development, energy homeostasis and metabolic function. The journal also welcomes preclinical and clinical trials of drugs that can modulate PPAR activity, with a view to treating chronic diseases and disorders such as dyslipidemia, diabetes, adipocyte differentiation, inflammation, cancer, lung diseases, neurodegenerative disorders, and obesity.