CXCR4/CXCL12轴在结直肠癌中的研究进展

Zhi-Yu Song , Zu-Hua Gao , Xian-Jun Qu
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引用次数: 4

摘要

趋化因子CXCL12 (SDF-1)是一种结合其细胞表面受体CXCR4的细胞外趋化因子。CXCL12/CXCR4轴被认为在癌细胞迁移中起重要作用。近年来,CXCR4在结直肠癌(CRC)的恶性肿瘤中被发现异常表达,它在肿瘤的增殖、血管生成和转移扩散等方面起着至关重要的作用。已经确定了与CXCR4/CXCL12轴相关的多种细胞内信号转导级联和效应因子,如MAPK、PI-3K/Akt和Wnt。目前,CXCR4/CXCL12作为结直肠癌治疗靶点的潜在作用已被关注。本文就近年来CXCL12/CXCR4轴在结直肠癌发展中的研究进展进行综述。
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A review of CXCR4/CXCL12 axis in colorectal cancer

The chemokine CXCL12 (SDF-1) is an extracellular chemokine which binds to its cell surface receptor CXCR4. The axis of CXCL12/CXCR4 has been considered to play an important role for cancer cell migration. Recently, the aberrant expression of CXCR4 has been found during the malignancy of colorectal cancer (CRC), where it plays a crucial role in, among others, the proliferation, angiogenesis and metastatic spread. Various intracellular signal transduction cascades and effectors related to the CXCR4/CXCL12 axis have been determined, such as MAPK, PI-3K/Akt and Wnt. Currently, the potential role of CXCR4/CXCL12 as the therapeutic target for treatment of CRC has been focused. In this review, we summarized recent research on CXCL12/CXCR4 axis in the development of CRC.

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