{"title":"适当素因子B(富含甘氨酸的β -糖蛋白或C3促活化剂)-多态性:遗传和生化方面。首次应用于亲子关系案件。","authors":"G Mauff, K Hummel, G Pulverer","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Determination of genetic properdin factor B(Bf) polymorphism was carried out in immunofixation electrophoresis. Genetics of factor B were also studied after ageing, conversion with cobra venom and neuraminidase. In population studies the distribution of factor B in a West German population of 1245 non-related individuals was found to be: Bf F 2.73%, Bf FS 28.43%, Bf S 65.38%. Rare phenotypes (F 1F,F 1S, FS 1, SS 1) were seen in 3.46%. In addition a new variant, designated F1.6S, was observed. The application of factor B polymorphism to 68 paternity cases is discussed.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 4","pages":"327-38"},"PeriodicalIF":0.0000,"publicationDate":"1975-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator)-polymorphism: genetic and biochemical aspects. First application to paternity cases.\",\"authors\":\"G Mauff, K Hummel, G Pulverer\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Determination of genetic properdin factor B(Bf) polymorphism was carried out in immunofixation electrophoresis. Genetics of factor B were also studied after ageing, conversion with cobra venom and neuraminidase. In population studies the distribution of factor B in a West German population of 1245 non-related individuals was found to be: Bf F 2.73%, Bf FS 28.43%, Bf S 65.38%. Rare phenotypes (F 1F,F 1S, FS 1, SS 1) were seen in 3.46%. In addition a new variant, designated F1.6S, was observed. The application of factor B polymorphism to 68 paternity cases is discussed.</p>\",\"PeriodicalId\":23768,\"journal\":{\"name\":\"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie\",\"volume\":\"150 4\",\"pages\":\"327-38\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
采用免疫固定电泳法测定遗传特性因子B(Bf)多态性。衰老后，与眼镜蛇毒液和神经氨酸酶的转化也研究了因子B的遗传学。在种群研究中，1245个非相关个体在西德人群中的B因子分布为:Bf - F 2.73%， Bf - FS 28.43%， Bf - S 65.38%。罕见表型(F 1F、F 1S、FS 1、SS 1)占3.46%。此外，一个新的改型，命名为F1.6S，被观察到。讨论了因子B多态性在68例亲子鉴定中的应用。
Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator)-polymorphism: genetic and biochemical aspects. First application to paternity cases.
Determination of genetic properdin factor B(Bf) polymorphism was carried out in immunofixation electrophoresis. Genetics of factor B were also studied after ageing, conversion with cobra venom and neuraminidase. In population studies the distribution of factor B in a West German population of 1245 non-related individuals was found to be: Bf F 2.73%, Bf FS 28.43%, Bf S 65.38%. Rare phenotypes (F 1F,F 1S, FS 1, SS 1) were seen in 3.46%. In addition a new variant, designated F1.6S, was observed. The application of factor B polymorphism to 68 paternity cases is discussed.
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