{"title":"免疫小鼠脾脏dna合成和dna甲基化。","authors":"D Lutz, H Kröger, W Uecker, D Kubsch, E Mertens","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Methylation of spleen DNA was investigated in mice immunized with bovine serum albumin. At the time of the highest incorporation of deoxythymidine into DNA -24 hours after antigen application--there is an elevated DNA methylation rate as shown by the transfer of the methyl group of methionine to DNA cytosine as well as by the conversion of DNA cytosine to DNA 5-methyl-cytosine. There is no difference in the methylation rate between bulk DNA and satellite DNA.</p>","PeriodicalId":23768,"journal":{"name":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","volume":"150 5","pages":"424-31"},"PeriodicalIF":0.0000,"publicationDate":"1975-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"DNA-synthesis and DNA-methylation in the spleen of immunized mice.\",\"authors\":\"D Lutz, H Kröger, W Uecker, D Kubsch, E Mertens\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Methylation of spleen DNA was investigated in mice immunized with bovine serum albumin. At the time of the highest incorporation of deoxythymidine into DNA -24 hours after antigen application--there is an elevated DNA methylation rate as shown by the transfer of the methyl group of methionine to DNA cytosine as well as by the conversion of DNA cytosine to DNA 5-methyl-cytosine. There is no difference in the methylation rate between bulk DNA and satellite DNA.</p>\",\"PeriodicalId\":23768,\"journal\":{\"name\":\"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie\",\"volume\":\"150 5\",\"pages\":\"424-31\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1975-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
DNA-synthesis and DNA-methylation in the spleen of immunized mice.
Methylation of spleen DNA was investigated in mice immunized with bovine serum albumin. At the time of the highest incorporation of deoxythymidine into DNA -24 hours after antigen application--there is an elevated DNA methylation rate as shown by the transfer of the methyl group of methionine to DNA cytosine as well as by the conversion of DNA cytosine to DNA 5-methyl-cytosine. There is no difference in the methylation rate between bulk DNA and satellite DNA.
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