如何才能成功实现完全替代动物手术的最终目标?

Christiane Baumgartl-Simons, Christiane D. Hohensee
{"title":"如何才能成功实现完全替代动物手术的最终目标?","authors":"Christiane Baumgartl-Simons, Christiane D. Hohensee","doi":"10.1163/9789004391192_004","DOIUrl":null,"url":null,"abstract":"2373. [ online] Available at: https:/ /www.mattek.com/reference-library/ identification-of-endocrine-disruptors-using-an-organotypic-vaginal-tissue­ model/ [Accessed 6 August 2017 ]. Ayehunie, S., Landry, T., Hayden, P. and Klausner M. ( 2016 ). Pre-validation of in vitro in vivo assays for vaginal irritation. In: Society of Toxicology 2016 Annual Meeting. [ online] Available at: https:/ /www.mattek.com/join-us-at-sot-2016/ [ Accessed 6 August 2017 ] . Baumgartl-Simons, C. (2017). Das Ende muss endlich wirksam verfolgt werden. Tierrechte, 02, p. 4. [ online] Available at: https:/ /www.tierrechte.de/images/stories/ Presse_und_Magazin_Tierrechte/Magazin_2-17 _.pdf [ Accessed nJanuary 2018] . BfR(2017a) .NationalerAusschussTierschutzgesetz-EJR. [ online ]Availableat:http:/ /www .bfr.bund.de/ de/nationaler_ausschuss_tierschutzgesetz.html [ Accessed 2 August 2017] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access 116 BAUMGARTL-SIMONS AND HOHENSEE BfR (2017b). Fragen und Antworten zum Deutschen Zentrum zum Schutz von Versuch­ stieren (B/3R). [ online] Available at: http://www.bfr.bund.de/cm/343/fragen-und­ antworten-zum-deutschen-zentrum-zum-schutz-von-versuchstieren-bf3r.pdf [ Accessed 4 August 2017 ] . BMBF (20n). Bekanntmachung des Bundesministeriums far Bi/dung und Forschung von Richtlinien zur Forderung ,,e:Bio lnnovationswettbewerb Systembiologie\" Vom 17. Dezember 2010. [ online] Available at: https:/ /www.bmbf.de/foerderungen/ bekanntmachung.php?B=6o8 [ Accessed 4 August 2017 ] . BMBF (2015a). Bekanntmachung des Bundesministeriumsfar Bildung und Forschung von Richtlinien zur Forderung der \"Multilateralen Zusammenarbeit in Computational Neuroscience: Deutsch/and USA Israel Frankreich\" Vom 16. Juli 2015. [ online] Available at: https:/ /www.bmbf.de/foerderungen/bekanntmachung-1068.html [ Accessed 4 August 2017 ] . BMBF ( 2015b ). Bekanntmachung: Richtlinie zur Forderung von ''Altemativmethoden zum Tierversuch': Bundesanzeiger vom 24.12.2015. [ online] Available at: https:/ /www. bmbf.de/foerderungen/bekanntmachung.php?B=n24 [ Accessed 6 August 2017 ] . BMBF ( 2016). Lebenswissenschaftliche GrundlagenforschungALtemativenzum Tierver­ such. [ online] Available at: https:/ /www.bmbf.de/de/altemativen-zum-tierversuch -412.html [ Accessed 6 August 2017 ] . Buchmann Institute for Molecular Life Sciences (2017). BMLS Drug Delivery and 3R-models. [ online] Available at: https:/ /www.bmls.de/Drug_Delivery_and-3R­ Models/people.html [Accessed 6 August 2017 ] . Bundesministerium fiir Justiz und Verbraucherschutz ( 2017 ) . §46 TierSch Vers VEinzel­ norm. [ online] Available at: http://www.gesetze-im-intemet.de/tierschversv/_46. html [ Accessed 4 August 2017 ] . Bundesministerium fiir Wirtschaft und Energie (2017). Forderdatenbank Inhalts­ verzeichnis. [ online] Available at: http://www.foerderdatenbank.de/Foerder-DB/ Navigation/Foerderrecherche/inhaltsverzeichnis.html?get=ea6079646dcbaffo7 8c1252foafa99d6;views;document&doc=13310 [ Accessed 4 August 2017 ] . CAAT (n.d. a). CAAT History. [ online] Available at: http://caat.jhsph.edu/about/history .html [Accessed 26 July 2018 ] . CAAT ( n.d. b ) . About Us: Center for Alternatives to Animal Testing. [ online] Available at: http://caat.jhsph.edu/about/index.html [ Accessed 26 July 2018 ] . Chen, S., S.E. Palma-Vera, M. Langhammer, S.P. Galuska, B.C. Braun, E . Krause, A. Lucas-Hahn and J. Schoen (2017). An Air-liquid Interphase Approach for Model­ ing the Early Embryo-maternal Contact Zone. Scientific Reports, 7, 42298 [ online] Available at: https:/ /www.nature.com/articles/srep42298 [Accessed 12 February 2018 ] . Committee on Toxicity Testing and Assessment of Environmental Agents ( 2007 ). Tox­ icity Testing in the 21st Century: A Vision and a Strategy. [ online] Available at: http:// Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access HOW CAN THE FINAL GOAL OF COMPLETELY REPLACING ANIMAL 117 dels.nas.edu /resources/static-assets/ materials-based-on-reports/ reports-in-brief/ Toxicity_Testing_final.pdf [ Accessed 5 August 2017 ] . Cosmetics Europe ( 2017 ) . Promoting Science and Research. [ online] Available at: https:/ / www.cosmeticseurope.eu/how-we-take-action/promoting-science-research/ [ Ac­ cessed 4 August 2017 ] . Cronin, M. (2017). Non-animal Approaches The Way Forward. Report on a Euro­ pean Commission Scientific Conference. Brussels, Belgium. December 6-7, 2016. [ online] Available at: http:/ /ec.europa.eu/environment/chemicals/lab_animals/3r/ pdf/scientific_conference/non_animal_approaches_conference_report.pdf [ Accessed 26 July 2018] . Der Regierende Biirgermeister Senatskanzlei Berlin (2017). Senat beschliefit Entwurf des Charite-Vertrages 2018-2022. Pressemitteilung [ online] Available at: https:/ /www. berlin.de / rbmskzl/ aktuelles / pressemitteilungen/ 2017 / pressemitteilung.617676. php#search=0/022Tierversuch*0/022 [ Accessed 4 August 2017 ]. D FG ( 2017 ). Hochdurchsatzverfahren: D FG fordert modeme Forschungsinfrastrukturen in den Lebenswissenschaften. [ online] Available at: http:/ /www.dfg.de/service/ presse/pressemitteilungen/2017 /pressemitteilung_nr_28/index.html [ Accessed 6 August 2017] . Eddie, S.L., J.J. Kim, T.K. Woodruff and J.E. Burdette (2015). Microphysiological Mod­ eling of the Reproductive Tract: A Fertile Endeavor. Experimental Biology and Medicine, 239(9), pp. 1192-12O2. EPAA (2017). European Partnership for Alternative Approaches to Animal Testing Wachstum European Commission. [ online] Available at: https:/ /ec.europa.eu/ growth/sectors/chemicals/epaa_de [ Accessed 6 August 2017 ] . Epithelix ( 2017 ) . Toxicity of Inhaled Products: Acute, Long Term or Repeated Dose Test­ ing of Drugs/Formulations or Xenobiotics on Reconstructed Human Airway Tissues (MucilAirJ. [ online] Available at: http:/ /www.epithelix.com/services/toxicity-of­ inhaled-products [ Accessed 6 August 2017 ] . Esch, E.W., A. Babinski and D. Huh (2015). Organs-on-Chips at the Frontiers of Drug Discovery. Nature Reviews Drug Discovery 14, pp. 248-260. Ettel, A. ( 2018). Es wird nicht moglich sein, Tierversuche zu ersetzen. Welt. [ online] Avail­ able at: https:/ /www.welt.de/wirtschaft/article1734934oo/Tierversuche-Laengst­ nicht-alle-Tests-dienen-der-Forschung.html [Accessed 13 Feb. 2018] . EU-NETVAL (2018). EU-NETVAL (European Union Network of Laboratories for the Validation of Alternative Methods). [ online] Available at: https:/ /eurl-ecvamJrc. ec.europa.eu/eu-netval [ Accessed 12 February 2018] . EU-ToxRisk (2016). EU-ToxRisk An integrated European ''Flagship\" Pro­ gram Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century. [ online] Available at: http:/ /www.eu-toxrisk.eu/ [ Accessed 2 August 2017 ] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access 118 BAUMGARTL-SIMONS AND HOHENSEE EURL ECVAM (2017a). European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM). [ online] Available at: https:/ /eurl-ecvam.jrc.ec.europa.eu [ Accessed 4 August 2017] . EURL ECVAM (2017b). EURL ECVAM Recommendations. [online] Available at: https:/ /eurl-ecvam.jrc.ec.europa.eu/eurl-ecvam-recommendations [ Accessed 6 August 2017 ] . European Parliament (1986). Council Directive of 24 November 1986 on the Approxi­ mation of Laws, Regulations and Administrative Provisions of the Member States Regarding the Protection of Animals Used for Experimental and Other Scientific Purposes (86/609/EEC). Officialjoumal of the European Communities, L 358/1, p. 5. [ online] Available at: http:/ /eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=­ CELEX:31986Lo609&from=EN [Accessed 5 March 2018] . European Parliament (2010 ). Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals Used for Scientific Purposes. Officialjoumal of the European Communities, L 276, p. 33-79. [ online] Avail­ able at: http://eur-lex.europa.eu/legal-content/EN /TXT /?uri=CELEX:32010Loo63. [Accessed 3 August 2017 ] . FELASA ( n.d. ) . FELASA. [ online] Available at: http://www.felasa.eu/ [ Accessed 3 Au­ gust 2017 ] . Hartung, T. (2015). Food for Thought . . . The Human Whole Blood Pyrogen Test Lessons Learned in Twenty Years. ALTEX,32 (2), pp. 79-100. [ online] Available at: http:/ /altweb.jhsph.edu/altex/32_2/FFT.pdf [Accessed at 12 Feb. 2018] . Henneman, P., van P. Megchelen, M. Pijnappel, H. Smid, J. Wijnja and M. Zuidgeest (2015). In transitie! Nederland intemationaal toonaangevend in proefdiervrije innova­ ties. [ online] Available at: http://library.wur.nl/WebQuery/titel/2102149 [Accessed 26 July 2018] . HESPEROS (2017). Team. [ online] Available at: http:/ /www.hesperosinc.com/team/ [Accessed 10 January 2018] . Hildermann, L. (2015). Die EU-Tierversuchsrichtlinie und ihre Umsetzung in nation­ ales Recht: unionsund verfassungsrechtliche Aspekte. Dissertation. Universitat Trier. Hochschule fiir Technik und Wirtschaft Berlin, HTW-Berlin (2017). Bachelor-Life Sci­ ence Engineering. Official Website Hochschulefar Technik und Wirtschaft Berlin. [ on­ line] Available at: http://lse-bachelor.htw-berlin.de/studium/ [Accessed 6 August 2017 ] . Hoffmann, S., N. Mohle, M. Aufderheide, D. Steinritz, A. Tsoutsoulopoulos, A. Breit and 0. Krischenowski ( 2017 ). Validation of the CULT EX RFS Method to Assess the Acute Inhalation Toxicity of Dusts. [ online] Available at: https:/ /www.researchgate.net/ project/Validation-of-the-CULTEX-RFS-method-to-assess-the-acute-inhalation­ toxicity-of-dusts [Accessed 6 August 2017 ] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access HOW CAN THE FINAL GOAL OF COMPLETELY REPLACING ANIMAL 119 Hohensee, C. (2015). Fachgespriich zu Tierversuchsersatzverfahren im Deutschen Bund­ estag. [Blog] InVitro+Jobs. Availab","PeriodicalId":138056,"journal":{"name":"Animal Experimentation: Working Towards a Paradigm Change","volume":"39 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"How Can the Final Goal of Completely Replacing Animal Procedures Successfully Be Achieved?\",\"authors\":\"Christiane Baumgartl-Simons, Christiane D. Hohensee\",\"doi\":\"10.1163/9789004391192_004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"2373. [ online] Available at: https:/ /www.mattek.com/reference-library/ identification-of-endocrine-disruptors-using-an-organotypic-vaginal-tissue­ model/ [Accessed 6 August 2017 ]. Ayehunie, S., Landry, T., Hayden, P. and Klausner M. ( 2016 ). Pre-validation of in vitro in vivo assays for vaginal irritation. In: Society of Toxicology 2016 Annual Meeting. [ online] Available at: https:/ /www.mattek.com/join-us-at-sot-2016/ [ Accessed 6 August 2017 ] . Baumgartl-Simons, C. (2017). Das Ende muss endlich wirksam verfolgt werden. Tierrechte, 02, p. 4. [ online] Available at: https:/ /www.tierrechte.de/images/stories/ Presse_und_Magazin_Tierrechte/Magazin_2-17 _.pdf [ Accessed nJanuary 2018] . BfR(2017a) .NationalerAusschussTierschutzgesetz-EJR. [ online ]Availableat:http:/ /www .bfr.bund.de/ de/nationaler_ausschuss_tierschutzgesetz.html [ Accessed 2 August 2017] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access 116 BAUMGARTL-SIMONS AND HOHENSEE BfR (2017b). Fragen und Antworten zum Deutschen Zentrum zum Schutz von Versuch­ stieren (B/3R). [ online] Available at: http://www.bfr.bund.de/cm/343/fragen-und­ antworten-zum-deutschen-zentrum-zum-schutz-von-versuchstieren-bf3r.pdf [ Accessed 4 August 2017 ] . BMBF (20n). Bekanntmachung des Bundesministeriums far Bi/dung und Forschung von Richtlinien zur Forderung ,,e:Bio lnnovationswettbewerb Systembiologie\\\" Vom 17. Dezember 2010. [ online] Available at: https:/ /www.bmbf.de/foerderungen/ bekanntmachung.php?B=6o8 [ Accessed 4 August 2017 ] . BMBF (2015a). Bekanntmachung des Bundesministeriumsfar Bildung und Forschung von Richtlinien zur Forderung der \\\"Multilateralen Zusammenarbeit in Computational Neuroscience: Deutsch/and USA Israel Frankreich\\\" Vom 16. Juli 2015. [ online] Available at: https:/ /www.bmbf.de/foerderungen/bekanntmachung-1068.html [ Accessed 4 August 2017 ] . BMBF ( 2015b ). Bekanntmachung: Richtlinie zur Forderung von ''Altemativmethoden zum Tierversuch': Bundesanzeiger vom 24.12.2015. [ online] Available at: https:/ /www. bmbf.de/foerderungen/bekanntmachung.php?B=n24 [ Accessed 6 August 2017 ] . BMBF ( 2016). Lebenswissenschaftliche GrundlagenforschungALtemativenzum Tierver­ such. [ online] Available at: https:/ /www.bmbf.de/de/altemativen-zum-tierversuch -412.html [ Accessed 6 August 2017 ] . Buchmann Institute for Molecular Life Sciences (2017). BMLS Drug Delivery and 3R-models. [ online] Available at: https:/ /www.bmls.de/Drug_Delivery_and-3R­ Models/people.html [Accessed 6 August 2017 ] . Bundesministerium fiir Justiz und Verbraucherschutz ( 2017 ) . §46 TierSch Vers VEinzel­ norm. [ online] Available at: http://www.gesetze-im-intemet.de/tierschversv/_46. html [ Accessed 4 August 2017 ] . Bundesministerium fiir Wirtschaft und Energie (2017). Forderdatenbank Inhalts­ verzeichnis. [ online] Available at: http://www.foerderdatenbank.de/Foerder-DB/ Navigation/Foerderrecherche/inhaltsverzeichnis.html?get=ea6079646dcbaffo7 8c1252foafa99d6;views;document&doc=13310 [ Accessed 4 August 2017 ] . CAAT (n.d. a). CAAT History. [ online] Available at: http://caat.jhsph.edu/about/history .html [Accessed 26 July 2018 ] . CAAT ( n.d. b ) . About Us: Center for Alternatives to Animal Testing. [ online] Available at: http://caat.jhsph.edu/about/index.html [ Accessed 26 July 2018 ] . Chen, S., S.E. Palma-Vera, M. Langhammer, S.P. Galuska, B.C. Braun, E . Krause, A. Lucas-Hahn and J. Schoen (2017). An Air-liquid Interphase Approach for Model­ ing the Early Embryo-maternal Contact Zone. Scientific Reports, 7, 42298 [ online] Available at: https:/ /www.nature.com/articles/srep42298 [Accessed 12 February 2018 ] . Committee on Toxicity Testing and Assessment of Environmental Agents ( 2007 ). Tox­ icity Testing in the 21st Century: A Vision and a Strategy. [ online] Available at: http:// Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access HOW CAN THE FINAL GOAL OF COMPLETELY REPLACING ANIMAL 117 dels.nas.edu /resources/static-assets/ materials-based-on-reports/ reports-in-brief/ Toxicity_Testing_final.pdf [ Accessed 5 August 2017 ] . Cosmetics Europe ( 2017 ) . Promoting Science and Research. [ online] Available at: https:/ / www.cosmeticseurope.eu/how-we-take-action/promoting-science-research/ [ Ac­ cessed 4 August 2017 ] . Cronin, M. (2017). Non-animal Approaches The Way Forward. Report on a Euro­ pean Commission Scientific Conference. Brussels, Belgium. December 6-7, 2016. [ online] Available at: http:/ /ec.europa.eu/environment/chemicals/lab_animals/3r/ pdf/scientific_conference/non_animal_approaches_conference_report.pdf [ Accessed 26 July 2018] . Der Regierende Biirgermeister Senatskanzlei Berlin (2017). Senat beschliefit Entwurf des Charite-Vertrages 2018-2022. Pressemitteilung [ online] Available at: https:/ /www. berlin.de / rbmskzl/ aktuelles / pressemitteilungen/ 2017 / pressemitteilung.617676. php#search=0/022Tierversuch*0/022 [ Accessed 4 August 2017 ]. D FG ( 2017 ). Hochdurchsatzverfahren: D FG fordert modeme Forschungsinfrastrukturen in den Lebenswissenschaften. [ online] Available at: http:/ /www.dfg.de/service/ presse/pressemitteilungen/2017 /pressemitteilung_nr_28/index.html [ Accessed 6 August 2017] . Eddie, S.L., J.J. Kim, T.K. Woodruff and J.E. Burdette (2015). Microphysiological Mod­ eling of the Reproductive Tract: A Fertile Endeavor. Experimental Biology and Medicine, 239(9), pp. 1192-12O2. EPAA (2017). European Partnership for Alternative Approaches to Animal Testing Wachstum European Commission. [ online] Available at: https:/ /ec.europa.eu/ growth/sectors/chemicals/epaa_de [ Accessed 6 August 2017 ] . Epithelix ( 2017 ) . Toxicity of Inhaled Products: Acute, Long Term or Repeated Dose Test­ ing of Drugs/Formulations or Xenobiotics on Reconstructed Human Airway Tissues (MucilAirJ. [ online] Available at: http:/ /www.epithelix.com/services/toxicity-of­ inhaled-products [ Accessed 6 August 2017 ] . Esch, E.W., A. Babinski and D. Huh (2015). Organs-on-Chips at the Frontiers of Drug Discovery. Nature Reviews Drug Discovery 14, pp. 248-260. Ettel, A. ( 2018). Es wird nicht moglich sein, Tierversuche zu ersetzen. Welt. [ online] Avail­ able at: https:/ /www.welt.de/wirtschaft/article1734934oo/Tierversuche-Laengst­ nicht-alle-Tests-dienen-der-Forschung.html [Accessed 13 Feb. 2018] . EU-NETVAL (2018). EU-NETVAL (European Union Network of Laboratories for the Validation of Alternative Methods). [ online] Available at: https:/ /eurl-ecvamJrc. ec.europa.eu/eu-netval [ Accessed 12 February 2018] . EU-ToxRisk (2016). EU-ToxRisk An integrated European ''Flagship\\\" Pro­ gram Driving Mechanism-based Toxicity Testing and Risk Assessment for the 21st Century. [ online] Available at: http:/ /www.eu-toxrisk.eu/ [ Accessed 2 August 2017 ] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access 118 BAUMGARTL-SIMONS AND HOHENSEE EURL ECVAM (2017a). European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM). [ online] Available at: https:/ /eurl-ecvam.jrc.ec.europa.eu [ Accessed 4 August 2017] . EURL ECVAM (2017b). EURL ECVAM Recommendations. [online] Available at: https:/ /eurl-ecvam.jrc.ec.europa.eu/eurl-ecvam-recommendations [ Accessed 6 August 2017 ] . European Parliament (1986). Council Directive of 24 November 1986 on the Approxi­ mation of Laws, Regulations and Administrative Provisions of the Member States Regarding the Protection of Animals Used for Experimental and Other Scientific Purposes (86/609/EEC). Officialjoumal of the European Communities, L 358/1, p. 5. [ online] Available at: http:/ /eur-lex.europa.eu/legal-content/EN/TXT/PDF/?uri=­ CELEX:31986Lo609&from=EN [Accessed 5 March 2018] . European Parliament (2010 ). Directive 2010/63/EU of the European Parliament and of the Council of 22 September 2010 on the Protection of Animals Used for Scientific Purposes. Officialjoumal of the European Communities, L 276, p. 33-79. [ online] Avail­ able at: http://eur-lex.europa.eu/legal-content/EN /TXT /?uri=CELEX:32010Loo63. [Accessed 3 August 2017 ] . FELASA ( n.d. ) . FELASA. [ online] Available at: http://www.felasa.eu/ [ Accessed 3 Au­ gust 2017 ] . Hartung, T. (2015). Food for Thought . . . The Human Whole Blood Pyrogen Test Lessons Learned in Twenty Years. ALTEX,32 (2), pp. 79-100. [ online] Available at: http:/ /altweb.jhsph.edu/altex/32_2/FFT.pdf [Accessed at 12 Feb. 2018] . Henneman, P., van P. Megchelen, M. Pijnappel, H. Smid, J. Wijnja and M. Zuidgeest (2015). In transitie! Nederland intemationaal toonaangevend in proefdiervrije innova­ ties. [ online] Available at: http://library.wur.nl/WebQuery/titel/2102149 [Accessed 26 July 2018] . HESPEROS (2017). Team. [ online] Available at: http:/ /www.hesperosinc.com/team/ [Accessed 10 January 2018] . Hildermann, L. (2015). Die EU-Tierversuchsrichtlinie und ihre Umsetzung in nation­ ales Recht: unionsund verfassungsrechtliche Aspekte. Dissertation. Universitat Trier. Hochschule fiir Technik und Wirtschaft Berlin, HTW-Berlin (2017). Bachelor-Life Sci­ ence Engineering. Official Website Hochschulefar Technik und Wirtschaft Berlin. [ on­ line] Available at: http://lse-bachelor.htw-berlin.de/studium/ [Accessed 6 August 2017 ] . Hoffmann, S., N. Mohle, M. Aufderheide, D. Steinritz, A. Tsoutsoulopoulos, A. Breit and 0. Krischenowski ( 2017 ). Validation of the CULT EX RFS Method to Assess the Acute Inhalation Toxicity of Dusts. [ online] Available at: https:/ /www.researchgate.net/ project/Validation-of-the-CULTEX-RFS-method-to-assess-the-acute-inhalation­ toxicity-of-dusts [Accessed 6 August 2017 ] . Kathrin Herrmann and Kimberley Jayne 978-90-04-39119-2 Downloaded from Brill.com11 /11 /2019 09:57:0BPM via free access HOW CAN THE FINAL GOAL OF COMPLETELY REPLACING ANIMAL 119 Hohensee, C. (2015). Fachgespriich zu Tierversuchsersatzverfahren im Deutschen Bund­ estag. [Blog] InVitro+Jobs. 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引用次数: 2

摘要

2373. 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