Expression of Cell Adhesion Molecules in Preeclampsia

Aim: The serum P-Selectin and E-Selectin levels of preeclamptic patients attending General Hospital Owerri, Nigeria were evaluated. Materials and Methods: A case control study involving 200 primigravida (100 preeclamptic and 100 apparently healthy) between the ages of 20 and 32 years attending General Hospital Owerri. Fasting venous blood was collected for the determination of serum selectin. The serum selectins were estimated using enzyme linked immunoabsorbent assay (ELIZA). The Independent Student t test was used for statistical analysis. Results: The levels of P-Selectin and E-Selectin were significantly increased in preeclampsia (p<0.05), when compared with the control. Conclusion: The result suggests, that preeclampsia is linked with increased P-Selectin and E-Selectin level which may be useful for predicting the severity of pre-eclampsia.