协同方法:神经精神病学中的光生物调节、神经调节和药物治疗。一个有希望的策略,以提高PBM的采用和神经治疗疗效

Vahedifard Farzan
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摘要

光生物调节(PBM)是治疗神经精神疾病的有效方法,但其普遍接受和利用仍受到限制。在这封致编辑/专家意见的信中,我们解决了PBM研究人员和先驱面临的挑战,努力建立对其在神经精神病患者护理中的独家应用的普遍信心。尽管鼓励动物实验和选择积极的人体临床试验结果,但PBM的广泛接受受到一些因素的阻碍,包括有限的临床研究和与现有疗法(如药物治疗和心理治疗)的冲突。为了克服这些障碍,扩大PBM在神经精神病学中的采用和应用,我们提出了一种组合治疗方法。通过将PBM与认知行为疗法(CBT)或药物治疗等干预措施相结合,可以获得累积效应,使患者和治疗师都受益。患者可以获得多种治疗选择,并体验到联合治疗的协同效应,从而提高疗效。治疗师受益于扩大干预选择和提高病人护理质量。本研究引入了一种新的策略,将PBM与公认的干预措施(如CBT和药物治疗)相结合,以解决现有的挑战。这种结合的方法提供了一个实际的解决方案,以增加PBM在神经精神病学领域的接受和使用。为了支持这一战略,研究方向的转变势在必行。未来的研究应该调查PBM与其他神经干预措施的联合使用,如CBT或药物治疗。强有力的临床试验对比了“PBM + CBT”和“PBM(假)+ rTMS”这两组,这对于说服临床医生和患者接受PBM联合疗法至关重要。虽然PBM作为神经精神治疗的最终自主权是一个首要目标,但目前的联合治疗方法被证明是实用的、不可避免的和互利的。通过将传统疗法与PBM相结合,这种策略可能会促进神经精神病学更广泛的接受和应用。
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Synergistic Approach: Photobiomodulation, Neuromodulation, and Drug Therapy in Neuropsychiatry. A Promising Strategy to Enhance PBM Adoption and Neurotherapy Efficacy
Photobiomodulation (PBM) is an effective method for treating neuropsychiatric diseases, yet its universal acceptance and utilization remain constrained. In this Letter to the Editor/Expert Opinion, we address the challenges confronting PBM researchers and pioneers, striving to establish universal confidence in its exclusive application for neuropsychiatric patient care. Despite encouraging animal experiments and selecting positive human clinical trial outcomes, PBM’s widespread acceptance of PBM is hindered by factors including limited clinical studies and clashes with established therapies, such as drug therapy and psychotherapy. To overcome these obstacles and broaden PBM’s adoption and application of PBM in neuropsychiatry, we propose a combinatorial therapy approach. By integrating PBM with interventions such as Cognitive Behavioral Therapy (CBT) or drug therapy, a cumulative effect can be attained, benefiting both patients and therapists. Patients gain access to diverse treatment options and experience synergistic effects of combined therapies, thereby enhancing outcomes. Therapists benefit from expanded intervention choices and improved quality of patient care. This study introduces a novel strategy of amalgamating PBM with recognized interventions, such as CBT and drug therapy, to address existing challenges. This combined approach offers a practical solution to augment PBM acceptance and usage in the realm of neuropsychiatry. To endorse this strategy, a shift in the research direction is imperative. Future studies should investigate the amalgamated use of PBM with other neurointerventions, such as CBT or drug therapy. Robust clinical trials contrasting groups like “PBM + CBT” and “PBM (sham) + rTMS” are vital to persuade clinicians and patients toward embracing combined PBM therapies. Although PBM’s eventual autonomy as a neuropsychiatric treatment is an overarching goal, the present combination therapy approach proves practical, inevitable, and mutually beneficial. By bridging conventional therapies with PBM, this strategy may facilitate wider acceptance and utilization in neuropsychiatry.
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