动物模型对Unmad Gaja Kesari Rasa II学习记忆活动的评价

A. Jain
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摘要

在当今时代,每个领域都有竞争,因此出现了很多精神压力或精神障碍。在现代医学中,有各种各样的药物,如抗精神病药、抗癫痫药、情绪稳定药等,这些药物都有一定的副作用,如嗜睡、头晕、失忆等。但阿育吠陀当然有一个答案,经典文献中提到的物理神经疾病共有112种配方,即Unmad和Apasmar,其中共有25种草药矿物配方,Unmad Gaja Kesari Rasa II (UGK II)是其中之一。本研究评价了一种草药-矿物质化合物——龙须果沙II的学习记忆效果。采用Cook和broad模型评价学习记忆活动。30只wistar大鼠分为5组,每组6只。以外推因子0.018外推人体剂量,分别给予对照I、对照II、标准组、试验x、2x组药物剂量,进行学习和再学习试验,观察回避、逃避和无反应。现已确定UGK II (Rasa Kamdhenu,即;R.K Unmad Chikitsa/9-12)在学习和记忆活动中起着有效的作用。
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Evaluation of learning memory activity of Unmad Gaja Kesari Rasa II in Animal Models
In recent era there is competition in each and every field, so there is lot of mental stress or mental disorder seen. In modern medicine there are various drugs such as antipsychotic, antiepileptic, mood stabilizer etc. which have certain adverse effect such as drowsiness, dizziness, memory loss etc. But Ayurveda certainly has an answer, there are total 112 formulations mentioned in classical text for physco neurological disorder i.e., Unmad and Apasmar, out of these there are total 25 herbo-mineral formulations and Unmad Gaja Kesari Rasa II (UGK II) is one of them. Present study was done to evaluate Learning memory effect of Unmad Gaja Kesari Rasa II a herbo-mineral compound. Cook’s and widely model was used to evaluate learning memory activity. Total 30 wistar rats were classified into 5 groups each containing 6 rats. Human dose was extrapolated with extrapolating factor 0.018 and drug dose was given to control I and II, standard, test x and 2x group, after that learning and Relearning trails were given and avoidance, escape and no response was observed. It has been established that UGK II (Rasa Kamdhenu i.e.; R.K Unmad Chikitsa/9-12) has effective role in learning and memory activity.
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