数字微流控生物芯片多缺陷检测与诊断的迭代并行测试

Sourav Ghosh, Dolan Maity, Arijit Chowdhury, S. Roy, C. Giri
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引用次数: 3

摘要

数字微流控生物芯片是一个革命性的平台,可以同时执行复杂的生物分析操作。可靠性是数字微流控生物芯片的一个重要特征,它被用于许多安全关键应用,如即时健康评估、空气质量监测和食品安全测试。因此,为了确保生物芯片的正常功能,需要进行强大的离线和在线测试。测试可以在生产前进行,也可以与其他生物测定操作同时进行。在这项工作中,我们提出了一种有效的并行测试和诊断方案,以揭示所有故障电极的位置。目前文献中的大多数算法主要集中在单故障识别上。但生物芯片多重故障的诊断一直没有得到很好的解决。甚至有些算法错误地将非故障电极分类为故障电极。因此,本文主要研究多故障的正确、高效检测。此外,该测试方法能够与其他并发运行的生物测定操作一起检查给定的生物芯片。
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Iterative Parallel Test to Detect and Diagnose Multiple Defects for Digital Microfluidic Biochip
Digital microfluidic biochip is a revolutionizing platform to execute complex bioassay operations concurrently. Dependability is an important feature of digital microfluidic biochip which is used for many safety-critical applications, such as point-of-care health assessment, air-quality monitoring, and food-safety testing. Therefore to ensure the proper functionality of the biochip a robust offline and online testing is required. Testing can be done before manufacturing or concurrently with other bioassay operations. In this work, we are presenting an efficient parallel testing and diagnosis scheme to reveal the location of all the faulty electrodes. Most of the algorithms present in the literature are mainly focused on single fault identification. But the diagnosis of biochip with multiple faults is not addressed properly. Even some of the algorithms have incorrectly classified the non faulty electrode as a faulty electrode. Thus in this paper, we are mainly focusing on the detection of multiple faults, correctly and efficiently. Moreover, this testing method is capable to check the given biochip with other concurrently running bioassay operations.
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