-肾上腺素能受体基因多态性对心血管控制的影响

L. Matušková, B. Czippelova, Z. Turianikova, D. Švec, Z. Kolková, Z. Lasabová, M. Javorka
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引用次数: 0

摘要

$\upbeta$-肾上腺素能受体($\upbeta$-ARs)在心血管控制中起着关键作用。$\upbeta$-ARs的几个单核苷酸多态性(snp)可能影响心血管功能。我们的目的是探讨四种选定的$\upbeta$-ARs基因多态性与年轻健康受试者心血管控制相关措施之间的关系。我们的结论是,对反映心脏收缩强度和血压变异性的各种心血管特征的复杂分析可以揭示与$\upbeta$-ARs多态性相关的心血管交感神经控制的细微差异。
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Beta-adrenergic receptors gene polymorphisms effects on cardiovascular control
$\upbeta$-adrenergic receptors ($\upbeta$-ARs) playa pivotal role in the cardiovascular control. Several single nucleotide polymorphisms (SNPs) of $\upbeta$-ARs might influence cardiovascular function. We aimed to explore the associations between four selected $\upbeta$-ARs gene polymorphisms and cardiovascular control related measures in young healthy subjects. We conclude that complex analysis of various cardiovascular characteristics reflecting the strength of cardiac contraction and blood pressure variability can reveal subtle differences in cardiovascular sympathetic nervous control associated with $\upbeta$-ARs polymorphisms.
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