自体微碎片化脂肪细胞治疗距下关节骨性关节炎1例报告及文献复习

N. Niazi, J. Wong, A. Pillai
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摘要

创伤后距下关节关节炎并不常见,大多数是跟骨关节内骨折或距骨骨折的结果。一个独特的情况下管理距下关节关节炎描述使用自体微碎片脂肪细胞治疗。病例报告:我们提出了一个48岁的男性症状左距下关节关节炎,这是保守管理镇痛和多次类固醇注射。在手术过程中,从腹部抽出脂肪细胞,并将其转移到Lipogems试剂盒中进行脂肪组织的机械分解,时间约为20分钟。最后将10ml本品注射至距下关节。定期随访患者,收集视觉模拟评分(VAS)、曼彻斯特-牛津足部问卷(MOXFQ)和足踝能力测量评分(FAM-ADL)。结果:围手术期及随访期间均无腹部抽脂及关节内抽脂剂注射相关并发症发生。随访6个月时,VAS、MOX FQ和FAM-ADL评分均有改善。讨论:距下关节在后足负荷传递和运动中起核心作用,其错位和关节炎导致功能受损和疼痛。关节内注射脂肪细胞及其在退行性关节疾病中的再生潜力已经在文献中得到了很好的记录。Lipogem技术已被用于膝关节、髋关节和踝关节关节炎,但未被用于距下关节。结论:这一独特的病例报告表明,单剂量自体微碎片脂肪细胞治疗成功地改善了距下关节关节炎的功能,无并发症。
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Autologous Micro Fragmented Adipose Cells Therapy for Subtalar Joint Osteoarthritis – Case Report and Review of Literature
Introduction: Post-traumatic subtalar joint arthritis is uncommon and the majority results as a consequence of either an intra-articular calcaneal or talar fracture. A unique case of management of subtalar joint arthritis is described using autologous microfragmented adipose cells therapy. Case Report: We presented a 48-year-old male with symptomatic left subtalar joint arthritis, which was managed conservatively with analgesia and multiple steroid injections. During surgery, fat cells were aspirated from the abdomen and transferred to the Lipogems kit for mechanical breakdown of adipose tissue for around 20 minutes. Final 10ml of the product was injected into the subtalar joint. Patient was followed up at regular intervals and Visual analogue score (VAS), Manchester-Oxford Foot Questionnaire (MOXFQ) and Foot and Ankle Ability Measure scores (FAM-ADL) were collected. Results: No perioperative complications were noted relating to abdominal liposuction and intra-articular injection of lipoaspirate and during the follow-up period. Improvement in VAS, MOX FQ and FAM-ADL scores was noted up to 6 months of follow-up. Discussion: The subtalar joint plays a central role in load transmission and movement at the hindfoot and its malalignment and arthritis lead to impaired function and pain. Intra articular injections of fat cells and their regenerative potential in degenerative joint diseases have been well documented in literature. Lipogem technique has been used in knee, hip and ankle arthritis, but it is not documented to use in the subtalar joint. Conclusion: This unique case report demonstrated the successful use of a single-dose autologous micro fragmented fat cells therapy leading to functional improvement in subtalar joint arthritis with no complications.
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