2019冠状病毒病患者血小板计数与c反应蛋白的相关性研究

Rini Riyanti, Faliqul Bahar Muhammad, A. Handoko
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摘要

2019冠状病毒病(COVID-19)实验室检测对初始治疗和预测患者预后非常重要,但也有报道称COVID-19诊断检测结果假阴性。另一项研究报告了COVID-19患者生物标志物的变化,即血小板计数和c反应蛋白(CRP)水平。本研究探讨了COVID-19患者血小板计数与CRP的相关性。本研究采用横断面分析观察法,对2021年6月至8月在Soebandi博士医院和Jember Klinik医院住院的COVID-19患者进行二次数据分析。30例患者中,男性16例(53%),女性14例(47%);46 ~ 59岁年龄组18例(60%),·4岁年龄组12例(40%);入住ICU 8例(26.67%)。COVID-19患者血小板计数与CRP呈负相关(r = -0.733;p < 0.001)。血小板计数和CRP与COVID-19患者严重程度的预后和预测因素有很强的相关性。需要进一步研究COVID-19的其他生物标志物分析,以获得更多患者严重程度的预后和预测因素。
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Correlation between Platelets Count and C-reactive Protein in COVID-19 Patient in Jember Regency
The laboratory test for Coronavirus disease 2019 (COVID-19) is very important for initial treatment and predicting the prognosis of the patients, but there have been reports of false negative COVID-19 diagnostic test results. Another study reported changes in COVID-19 patient biomarkers, namely platelets count and C-Reactive Protein (CRP) levels. This study investigated the correlation between platelet count and CRP in COVID-19 patients. This study was conducted using a cross-sectional analytic observational method, through secondary data analysis of COVID-19 patients who hospitalized between June – August 2021 at Dr. Soebandi Hospital and Jember Klinik Hospital. Of 30 patients, there were 16 male patients (53%) and 14 female patients (47%); 18 patients in the 46-59 years old age group (60%) and 12 patients in ≤ 4 years old (40%) age group; and there were 8 patients admitted to ICU (26.67%). There was a negative correlation between platelet count and CRP in COVID-19 patients (r = -0.733; p<0.001). A strong correlation between platelet count and CRP is related to prognostic and predictive factors of severity in COVID-19 patients. Further studies about the analysis of other biomarkers in COVID-19 are needed to obtain more prognostic and predictive factors of severity in patient.
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