可吸收壳聚糖基质——一种很有前途的生物材料

T. Chandy, C. P. Sharma
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引用次数: 4

摘要

壳聚糖是一种天然多糖,具有与糖胺聚糖相似的结构特征,似乎是无毒的和可生物吸附的。壳聚糖基质在生物医学上的广泛应用,如去除胆红素、血液透析膜、药物输送、木炭包封壳聚糖珠(ACCB)去除毒素、特异性免疫吸附基质、壳聚糖包覆羟基磷灰石作为骨科和牙科透析材料等。因此,壳聚糖是一种可行的材料,它可以根据需要制成各种形式,如珠状、颗粒状、片状、膜状等。有了这些生物医学上的用途,壳聚糖似乎是未来固定组织界面的一个希望。本文强调了这种新型基质在此类生物医学应用中的重要性。
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Resorbable chitosan matrix-a promising biomaterial for the future
Chitosan, a natural polysaccharide, having structural characteristics similar to glycosaminoglycans seems to be non-toxic and bioadsorbable. The chitosan matrix has been extensively investigated in the author's laboratory for a variety of biomedical applications, such as the removal of bilirubin, haemodialysis membranes, for delivery of drugs, charcoal encapsulated chitosan beads (ACCB) for toxin removal, specific immunoadsorbent matrix, chitosan coated hydroxyapatite as orthopaedic and dental dialysis materials etc. Thus, chitosan is a viable material, which can be fabricated into various forms, such as beads, granules tablets, membranes etc, as per requirements. With all these variety of biomedical uses, it appears, chitosan may be a future promise for anchoring the tissue interfaces. This paper highlights the importance of this novel matrix for such biomedical applications.
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