{"title":"基于草药的强效抗氧化剂对化疗耐药卵巢腺癌细胞系的影响","authors":"J. Harpole, M. Tucci, H. Benghuzzi","doi":"10.1109/SBEC.2016.11","DOIUrl":null,"url":null,"abstract":"This study investigates conventional delivery of thymoquinone (TQ) and epigallocatechin-3-gallate (EGCG) when applied to Caov-3 and SK-OV-3 ovarian like cell lines. Culturing the cells and assessment of functional activities were conducted following standard lab protocols. The results revealed: (1) an increase in the SK-OV-3 cell protein levels following treatment with TQ+EGCG which was statistically different (p<;0.05) at 24 and 48 hours; (2) nitric oxide levels were statistically different (p<;0.05) following the administration of EGCG and TQ+EGCG at 24 and 48 hours for Caov-3 and TQ at 72 hours for SK-OV-3; and (3) glutathione levels were statistically different (p<;0.05) following the administration of TQ and EGCG to the SK-OV-3 cell line at 72 hours. Overall conclusion of this study demonstrates that exposure of potent herbal based anti-oxidant extracts may potentially interfere with the functional and mitotic activity of ovarian cancer cells.","PeriodicalId":196856,"journal":{"name":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effect of Herbal Based Potent Antioxidants on Chemotherapy Resistant Ovarian Adenocarcinoma Cell Lines\",\"authors\":\"J. Harpole, M. Tucci, H. Benghuzzi\",\"doi\":\"10.1109/SBEC.2016.11\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"This study investigates conventional delivery of thymoquinone (TQ) and epigallocatechin-3-gallate (EGCG) when applied to Caov-3 and SK-OV-3 ovarian like cell lines. Culturing the cells and assessment of functional activities were conducted following standard lab protocols. The results revealed: (1) an increase in the SK-OV-3 cell protein levels following treatment with TQ+EGCG which was statistically different (p<;0.05) at 24 and 48 hours; (2) nitric oxide levels were statistically different (p<;0.05) following the administration of EGCG and TQ+EGCG at 24 and 48 hours for Caov-3 and TQ at 72 hours for SK-OV-3; and (3) glutathione levels were statistically different (p<;0.05) following the administration of TQ and EGCG to the SK-OV-3 cell line at 72 hours. Overall conclusion of this study demonstrates that exposure of potent herbal based anti-oxidant extracts may potentially interfere with the functional and mitotic activity of ovarian cancer cells.\",\"PeriodicalId\":196856,\"journal\":{\"name\":\"2016 32nd Southern Biomedical Engineering Conference (SBEC)\",\"volume\":\"25 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2016-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"2016 32nd Southern Biomedical Engineering Conference (SBEC)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/SBEC.2016.11\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"2016 32nd Southern Biomedical Engineering Conference (SBEC)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/SBEC.2016.11","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Effect of Herbal Based Potent Antioxidants on Chemotherapy Resistant Ovarian Adenocarcinoma Cell Lines
This study investigates conventional delivery of thymoquinone (TQ) and epigallocatechin-3-gallate (EGCG) when applied to Caov-3 and SK-OV-3 ovarian like cell lines. Culturing the cells and assessment of functional activities were conducted following standard lab protocols. The results revealed: (1) an increase in the SK-OV-3 cell protein levels following treatment with TQ+EGCG which was statistically different (p<;0.05) at 24 and 48 hours; (2) nitric oxide levels were statistically different (p<;0.05) following the administration of EGCG and TQ+EGCG at 24 and 48 hours for Caov-3 and TQ at 72 hours for SK-OV-3; and (3) glutathione levels were statistically different (p<;0.05) following the administration of TQ and EGCG to the SK-OV-3 cell line at 72 hours. Overall conclusion of this study demonstrates that exposure of potent herbal based anti-oxidant extracts may potentially interfere with the functional and mitotic activity of ovarian cancer cells.
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