Effectivity Test of Loquat (Eriobotrya japonica (Thunb.) Lindl.) Leaves Extract on the Incision Wound Healing in Mice (Mus musculus L.)

: The wound healing process is divided into four phases; 1) coagulation 2) inflammatory 3) proliferation 4) remodelling. Loquat ( Eriobotrya japonica (Thunb.) Lindl.) leaf contains triterpenoid, flavonoid, alkaloid, and tannin as anti-inflammation, antibacterial, anti-allergic that can accelerate the wound healing process. The aims of this research were to find out the effectiveness of ethanol extract of loquat leaves and to examine the histological appearance of wound healing process on mice’s skin in day 14 th . This research used 25 male mice ( Mus musculus L.) that were divided into five different treatment groups. The treatment groups were treated with two control groups; povidone-iodine (K+) and without treatment (K-) and loquat leaves ethanol extract with three concentration of 15% (PI), 30% (PII), and 45% (PIII). Incision wound was made into 1 cm length, the ointments were applied onto the wound and observed for twice a day in 14 days. Histological preparation was made to calculate epithelial thickness, fibroblasts, and lymphocytes. The data were analyzed statistically using SPSS. The result of this research showed significant difference of average time span of wound healing of each group's, K-, K+, PI, PII, and PIII was subsequently 8 days, 9.2 days, 7.6 days, 8.4 days, and 9.4 days, with p=0.048 (p<0.05). Histological observations showed the average of epithelial thickness, fibroblasts, and lymphocytes in the treatment group PI is higher than the other treatment groups. In conclusion, loquat leaves ethanol extract with concentration 15% (PI) was the most effective to accelerate the wound healing process.