治疗癌症相关血栓:专门的服务可能会有所帮助

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引用次数: 0

摘要

癌症是发生血栓栓塞(VTE)的唯一最重要的危险因素。由于各种原因,癌症患者出血的风险增加[1]。低分子量肝素(LMWH)多年来一直是治疗的标准[2]。与低分子肝素相比,直接作用口服抗凝剂(DOACs)使用更简单,同样有效和安全[2]。然而,在癌症患者中存在与DOACs相关的几个问题。它们与胃肠道和尿路上皮恶性肿瘤的药物间相互作用和出血风险有关[3]。作者全面总结了与癌症患者静脉血栓栓塞管理相关的现有证据。
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Managing cancer associated thrombosis (cat): a dedicated service may help
Cancer is single most important risk factor for developing thromboembolism (VTE). Cancer patients are at increased risk of bleeding due to various reasons [1]. Low molecular weight heparin (LMWH) remained the standard of care for many years [2]. Direct acting oral anticoagulants (DOACs) are simpler to administer and equally effective and safe as compared to LMWH [2]. However, there are several concerns associated with DOACs in cancer patients. They are related to drug-to-drug interactions and risk of bleeding in gastrointestinal and urothelial malignancies [3]. Authors have comprehensively summarized the available evidence related to managing venous thromboembolism in cancer patients.
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