Exploring the mechanism of action and efficacy of Shi-Pi-San in the treatment of ascites in cirrhosis based on intestinal microbiota

Objective: To investigate the mechanism of action and efficacy of Shi-Pi-San (SPS) in the treatment of cirrhotic ascites based on intestinal flora and to provide new ideas for clinical research. Methods: We searched PubMed, CNKI, Wanfang and Wipu Chinese journal databases to collect randomized controlled trials of SPS in the treatment of cirrhotic ascites, extracted relevant data, and summarized them to analyze the relationship between intestinal flora and cirrhotic ascites. Results: The disorder of intestinal flora can lead to cirrhotic ascites, and the treatment of cirrhotic ascites with SPS has good efficacy, and SPS has positive effects in improving the status of intestinal flora, increasing the abundance of flora and inhibiting the growth of pathogenic bacteria. Conclusion: SPS has good long-term efficacy in the treatment of cirrhotic ascites, but the side effects and dosage criteria have not been extensively studied in clinical practice.