基于聚类的神经性疼痛量表在疼痛医学中的亚组分析

Guangzhi Qu, Hui Wu, I. Sethi, C. Hartrick
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摘要

神经性疼痛(NeuP)通常比其他类型的慢性疼痛更难治疗。能够预测NeuP的结果,比如对特定治疗的反应和重返工作岗位,对患者和社会都有巨大的价值。在这项工作中,我们提出了一种使用神经性疼痛量表(NPS)的自适应聚类算法来开发一套标准患者模板。这些模板可能有助于研究NeuP的治疗反应。对108名受试者的基线数据进行了评估,结果证明了使用神经性疼痛量表(NPS)指标和我们提出的方法的有效性。
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Neuropathic Pain Scale Based Clustering for Subgroup Analysis in Pain Medicine
Neuropathic pain (NeuP) is often more difficult to treat than other types of chronic pain. The ability to predict outcomes in NeuP, such as response to specific therapies and return to work, would have tremendous value to both patients and society. In this work, we propose an adaptive clustering algorithm using the Neuropathic Pain Scale (NPS) to develop a set of standard patient templates. These templates may be useful in studying treatment response in NeuP. The approach is evaluated on 108 subjects' baseline data and results demonstrate the efficacy of utilizing neuropathic pain scale (NPS) metrics and our proposed method.
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