Polar grey relational analysis and its application in clinical trial

Using grey relational analysis (GRA) to analyze the grey relation between the cardiovascular medicine and fatality rate in hospitalized patients with acute coronary heart disease events in Beijing. A few valid data from the published results of the study "the fatality trends of acute coronary heart disease events in Beijing", which was a part of the National Key 75' Project, shared with WHO MONICA Project. GRA with order test of these data was performed. Positive grey relation was found between cardiovascular fatality rate and medicine including non-beta adrenoceptor blocker antiarrhythmics (NBAA), positive inotropic drugs (PID), calcium channel blockers (CCB). Negative grey relation between cardiovascular fatality rate and medicine including nitroglycerin (NG), antiplatelet agents (APT), beta-adrenoceptor blockers (BB) and ACEI was revealed. Grey relation between fatality rate and anticoagulants or thrombolytics was very weak. Cardiovascular fatality rate can be increased by CCB and NBAA, and decreased by NG, APT, BB and ACEI. GRA with order test is a more effective method in trial data.