子宫内膜增生性病变患者瘦素和可溶性瘦素受体水平的测定

Y. A. Lyzikova, M. V. Smirnova
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摘要

目标。测量子宫内膜增生性病变患者的瘦素和可溶性瘦素受体水平。材料和方法。本研究共纳入90例患者,其中子宫内膜增生性病变70例为主要组,子宫内膜形态正常的20例为对照组。采用酶免疫分析法测定血清中瘦素和可溶性瘦素受体的浓度,研究该病的临床和记忆特征。两组间血清瘦素水平比较无显著差异:研究组血清清瘦素水平为6,01 (3,64;7,50)ng/ml,对照组为- 6,44 (3,55;10,11)ng/ml (z = 0,61, p = 0,54)。主组患者可溶性瘦素受体水平明显降低,为8531 (5697;15895) ng/ml, 16181 (10696;p = 0.008, p = 2.614。子宫内膜增生过程患者的特点是可溶性瘦素受体水平降低,而与没有子宫内膜病理的患者相比,瘦素水平没有显著差异。确定的条件导致瘦素受体的信号传递缺陷和激素运输减少,导致瘦素的生物作用中断。确定可溶性瘦素受体< 14769 pg/ml,结合超声检查,可提高诊断措施检测子宫内膜增生过程的效率。
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Measurement of leptin and soluble leptin receptor levels in patients with endometrial hyperplastic processes
Objective. To measure leptin and soluble leptin receptor levels in patients with endometrial hyperplastic processes.Materials and methods. 90 patients were included in the study, 70 with hyperplastic endometrial processes made up the main group, 20 with morphologically normal endometrium were included in the comparison group. The concentration of leptin and the soluble leptin receptor in the blood serum was measured by the method of enzyme immunoassay, the clinical and anamnestic characteristics of the disease were studied Results. There were no significant differences between the groups when comparing serum leptin levels: in the study group, the hormone level was 6,01 (3,64;7,50) ng/ml, in the comparison group — 6,44 (3,55;10,11) ng/ml (z = 0,61, p = 0,54). The level of soluble leptin receptor was significantly lower in patients in the main group and was 8531 (5697; 15895) ng/ml, and 16181 (10696; 20251) ng/ml in the comparison group (z = 2.614, p = 0.008).Conclusion. Patients with endometrial hyperplastic processes are characterized by a decreased level of the soluble leptin receptor, whereas a leptin level has no significant differences compared to those in patients without endometrial pathology. The identified condition causes a defect in the signal transmission from the leptin receptor and a decrease in the hormone transport, leading to a disruption of the biological action of leptin. The established level of soluble leptin receptor < 14769 pg/ml, in combination with ultrasound examination, will increase the efficiency of diagnostic measures to detect endometrial hyperplastic processes.
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