{"title":"早衰和心血管疾病与HIV感染有关","authors":"M. Arbune","doi":"10.54044/rami.2021.04.05","DOIUrl":null,"url":null,"abstract":"\"Highly active antiretroviral therapy changed the paradigm of HIV infection, improving the prognosis of a deathly disease to a chronic manageable disease. Although the life expectancy of people with HIV is similar with general population, the persistence of inflammation is going to premature aging and excess comorbidities, relative to chronologic age. The mechanisms of immune dysfunction, inflammation, atherogenesis and dyslipidaemia in HIV positive people that are related to premature aging and cardiovascular risk, as well as the therapeutic strategies to prevent or improve the cardiovascular risk are reviewed in this communication. Keywords: HIV, inflammation, aging, cardiovascular risk, antiretroviral treatments\"","PeriodicalId":237638,"journal":{"name":"Romanian Archives of Microbiology and Immunology","volume":"82 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"PREMATURE AGING AND CARDIOVASCULAR DISEASES RELATED TO HIV INFECTION\",\"authors\":\"M. Arbune\",\"doi\":\"10.54044/rami.2021.04.05\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\\"Highly active antiretroviral therapy changed the paradigm of HIV infection, improving the prognosis of a deathly disease to a chronic manageable disease. Although the life expectancy of people with HIV is similar with general population, the persistence of inflammation is going to premature aging and excess comorbidities, relative to chronologic age. The mechanisms of immune dysfunction, inflammation, atherogenesis and dyslipidaemia in HIV positive people that are related to premature aging and cardiovascular risk, as well as the therapeutic strategies to prevent or improve the cardiovascular risk are reviewed in this communication. Keywords: HIV, inflammation, aging, cardiovascular risk, antiretroviral treatments\\\"\",\"PeriodicalId\":237638,\"journal\":{\"name\":\"Romanian Archives of Microbiology and Immunology\",\"volume\":\"82 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-12-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Romanian Archives of Microbiology and Immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.54044/rami.2021.04.05\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Romanian Archives of Microbiology and Immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.54044/rami.2021.04.05","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
PREMATURE AGING AND CARDIOVASCULAR DISEASES RELATED TO HIV INFECTION
"Highly active antiretroviral therapy changed the paradigm of HIV infection, improving the prognosis of a deathly disease to a chronic manageable disease. Although the life expectancy of people with HIV is similar with general population, the persistence of inflammation is going to premature aging and excess comorbidities, relative to chronologic age. The mechanisms of immune dysfunction, inflammation, atherogenesis and dyslipidaemia in HIV positive people that are related to premature aging and cardiovascular risk, as well as the therapeutic strategies to prevent or improve the cardiovascular risk are reviewed in this communication. Keywords: HIV, inflammation, aging, cardiovascular risk, antiretroviral treatments"
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