钠钾电导分岔检测某些神经系统疾病

Anju Gera, T. Ahmed, Seema Nayak
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引用次数: 0

摘要

在神经学研究中,HH模型和许多改进的形式已经成功地用于研究许多神经和其他兴奋性细胞疾病的神经动力学。医学研究表明,许多神经元疾病都与离子通道分叉有关。例如,钠离子通道动力学与癫痫有关,钾离子和钙离子通道也被发现与阿尔茨海默病有关。我们还知道,正常尖峰的阈值需要非线性(电压门控Na+和K+通道)和线性电流(泄漏通道)的贡献。因此,研究钙离子的分岔是非常重要的。
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Bifurcation of Sodium and Potassium Conductance for Detection of Some Neurological Disorder
In neurological research, the HH model and many modified forms have been successfully used to study the neurological dynamics of many neurological and other excitable cell disorders. It has been shown by medical researchers that many neuronal diseases are related to bifurcation of ion channels. For example, sodium channel dynamics are involved in epilepsy, potassium and calcium channels have also been found to be associated with Alzheimer’s disease. It is also known that the threshold for normal spiking requires contribution from both non-linear (voltage-gated Na+ and K+ channels) and linear currents (leak channel). Therefore, study of bifurcation of calcium ion is very important.
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