Are Nodular Goiter Patients Previously Treated with L-Thyroxine have Unfavorable Outcomes after Surgery Compared to Patients without Medical Treatment?

This systematic review aimed to analyze the literature on PubMed Database regarding studies which compare the patient’s post-thyroidectomy outcomes, between those who were treated with L-Thyroxine prior to surgery and those who underwent to thyroidectomy without hormonal suppressive therapy. 500 articles were screened, 11 articles were selected, which were related to the outcomes of interests. Among all these articles with outcome interests, no article is appropriate to the research question of our investigation. The outcomes of surgical treatment of nodular goiter patients, depending on using L-Thyroxine treatment in anamnesis, are very interesting and could bring light to some issues of endocrinology. There is need for further research on this topic to generate relevant evidence on use of L-Thyroxine.