The rate of perforation in gastric tumors has been reported to be between 0.5 and 3.9%. Because the tumor is not diagnosed at the moment, or the tumor's stage is unknown, repairing the perforation site is recommended rather than resection. The first thing that comes to mind as a repair method is omentoplasty, but other alternatives can be applied in cases where this is not possible. In our case report, we aimed to present gastric tumor perforation repair with a falciform ligament in a case of linitis plastica under chemotherapy accompanied by peritoneal carcinomatosis.
{"title":"Gastric Tumor Perforation Repair with Falciform Ligament","authors":"T. Aktokmakyan","doi":"10.23880/ijsst-16000164","DOIUrl":"https://doi.org/10.23880/ijsst-16000164","url":null,"abstract":"The rate of perforation in gastric tumors has been reported to be between 0.5 and 3.9%. Because the tumor is not diagnosed at the moment, or the tumor's stage is unknown, repairing the perforation site is recommended rather than resection. The first thing that comes to mind as a repair method is omentoplasty, but other alternatives can be applied in cases where this is not possible. In our case report, we aimed to present gastric tumor perforation repair with a falciform ligament in a case of linitis plastica under chemotherapy accompanied by peritoneal carcinomatosis.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116980390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mesenteric cystic lymphangioma is an uncommon benign abdominal mass. This is a case of a 40-year-old female who presented to the hospital with recurrent abdominal pain and distention. Computed Tomography and magnetic resonance imaging tests suggested a mesenteric cyst. The patient underwent laparotomy which confirmed the presence of a mesenteric cyst along with small bowel narrowing at the site of the cyst caused by multiple adhesive bands released during the procedure. The cyst was found and excised approximately 200 cm away from the ileocecal junction, and was pathologically confirmed to be a mesenteric cystic lymphangioma. These findings support that mesenteric cystic lymphangioma could cause chronic abdominal pain and intestinal obstruction.
{"title":"Mesenteric Cystic Lymphangioma Induced Recurrent Abdominal Pain And Signs of Intestinal Obstruction: A Case Report","authors":"Ebrahim Aldouseri","doi":"10.23880/ijsst-16000169","DOIUrl":"https://doi.org/10.23880/ijsst-16000169","url":null,"abstract":"Mesenteric cystic lymphangioma is an uncommon benign abdominal mass. This is a case of a 40-year-old female who presented to the hospital with recurrent abdominal pain and distention. Computed Tomography and magnetic resonance imaging tests suggested a mesenteric cyst. The patient underwent laparotomy which confirmed the presence of a mesenteric cyst along with small bowel narrowing at the site of the cyst caused by multiple adhesive bands released during the procedure. The cyst was found and excised approximately 200 cm away from the ileocecal junction, and was pathologically confirmed to be a mesenteric cystic lymphangioma. These findings support that mesenteric cystic lymphangioma could cause chronic abdominal pain and intestinal obstruction.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114945779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Innovation in Orthopaedic Surgery is motivated by the desire to improve implant longevity, maximise patient function and reduce postoperative complications. In recent years, other goals of innovation include reduced Health Care costs and improved efficiency of Health Care delivery. In Orthopaedic Surgery, the outcome of an innovation may not become apparent until a considerable period of time has passed after the introduction of the new technology.
{"title":"Past, Present and Future of THA and Hip Surgery: An Expert Opinion","authors":"S. Bernardino","doi":"10.23880/ijsst-16000175","DOIUrl":"https://doi.org/10.23880/ijsst-16000175","url":null,"abstract":"Innovation in Orthopaedic Surgery is motivated by the desire to improve implant longevity, maximise patient function and reduce postoperative complications. In recent years, other goals of innovation include reduced Health Care costs and improved efficiency of Health Care delivery. In Orthopaedic Surgery, the outcome of an innovation may not become apparent until a considerable period of time has passed after the introduction of the new technology.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115021907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mature teratomas are the most common benign testicular tumour during childhood. Epidermoid cyst are rare benign tumours, being more frequent before adolescence. We report so far the only case of ipsilateral and synchronous mature teratoma and epidermoid cyst in paediatric age.
{"title":"Testis Sparing Surgery in Double Testicular Tumor in a Child: Report of a Case","authors":"Bernardo Nunez","doi":"10.23880/ijsst-16000172","DOIUrl":"https://doi.org/10.23880/ijsst-16000172","url":null,"abstract":"Mature teratomas are the most common benign testicular tumour during childhood. Epidermoid cyst are rare benign tumours, being more frequent before adolescence. We report so far the only case of ipsilateral and synchronous mature teratoma and epidermoid cyst in paediatric age.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"411 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115610972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: There is need to determine the optimal management strategy for dirty abdominal surgical wounds. The aim of this study was to evaluate the post-operative wound complications in children whose dirty surgical wounds were closed primarily, in relation to those closed by delayed primary closure. Materials and Methods: This was a prospective evaluation of children, aged 15 years and younger, who had laparotomy for peritonitis in a teaching hospital in Enugu, Nigeria. This study covered a 5-year period. The following data were evaluated: patients’ age, gender, presenting symptoms, laboratory results at presentation, duration of symptoms before presentation, time interval between presentation and intervention, intra-operative finding, definitive operative procedure performed, complications of treatment, and outcome of treatment of the 2 groups of patients. Results: A total of 204 cases of peritonitis in children were operated upon during the study period. The incisions were closed by primary closure (Group A) in 104 (51%) while 100 (49%) surgical wounds were closed by delayed primary closure (Group B). More males were involved. All the patients had abdominal pain and about half the patients were anemic and had electrolyte imbalance at presentation. Typhoid intestinal perforation was the most common cause of peritonitis and closure of ileal perforation was the most frequent performed surgical procedure. Comparing the 2 groups of patients, surgical site infection and stitch related were less common in group B patients whose surgical incisions were closed by delayed primary closure. Conclusion: Delayed primary closure of dirty laparotomy incisions has less complication in terms of surgical site infection and stitch related complications. Therefore, delayed primary closure of dirty laparotomy wounds is advocated in pediatric population.
{"title":"Closure of Abdominal Incisions Following Laparotomy for Peritonitis in Children: Primary Closure or Delayed Primary Closure?","authors":"C. Emeka","doi":"10.23880/ijsst-16000173","DOIUrl":"https://doi.org/10.23880/ijsst-16000173","url":null,"abstract":"Background: There is need to determine the optimal management strategy for dirty abdominal surgical wounds. The aim of this study was to evaluate the post-operative wound complications in children whose dirty surgical wounds were closed primarily, in relation to those closed by delayed primary closure. Materials and Methods: This was a prospective evaluation of children, aged 15 years and younger, who had laparotomy for peritonitis in a teaching hospital in Enugu, Nigeria. This study covered a 5-year period. The following data were evaluated: patients’ age, gender, presenting symptoms, laboratory results at presentation, duration of symptoms before presentation, time interval between presentation and intervention, intra-operative finding, definitive operative procedure performed, complications of treatment, and outcome of treatment of the 2 groups of patients. Results: A total of 204 cases of peritonitis in children were operated upon during the study period. The incisions were closed by primary closure (Group A) in 104 (51%) while 100 (49%) surgical wounds were closed by delayed primary closure (Group B). More males were involved. All the patients had abdominal pain and about half the patients were anemic and had electrolyte imbalance at presentation. Typhoid intestinal perforation was the most common cause of peritonitis and closure of ileal perforation was the most frequent performed surgical procedure. Comparing the 2 groups of patients, surgical site infection and stitch related were less common in group B patients whose surgical incisions were closed by delayed primary closure. Conclusion: Delayed primary closure of dirty laparotomy incisions has less complication in terms of surgical site infection and stitch related complications. Therefore, delayed primary closure of dirty laparotomy wounds is advocated in pediatric population.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130475881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Endoscopic ablation under direct vision is the gold standard for treatment of posterior urethral valve. However, when the facilities are not available, Foley’s catheter balloon avulsion of the valve suffices. The aim of this study was to evaluate the initial outcome of management of children with posterior urethral valve treated by Foley’s catheter balloon avulsion. Materials and Methods: This was a retrospective study of children, aged 15 years and younger, who were treated for posterior urethral valves at the pediatric surgery unit of a teaching hospital in Enugu, Nigeria. The parameters evaluated included the age of the patient at presentation, duration of symptoms before presentation, time interval between presentation and intervention, presenting symptoms, procedure performed, post-intervention complications, duration of hospital stay and outcome of treatment. Results: A total of 24 children underwent catheter balloon avulsion during the study period. The mean age of the patients at presentation was 18 months and the mean duration of hospital stay was 18 days. Poor urinary stream and overflow incontinence were the most common presentations of the patients. Twenty-three out of 24 (96%) patients achieved full recovery with marked improvements in urinary stream and resolution of urinary symptoms. Patients who had hydronephrosis and vesicoureteric reflux before treatment, had resolutions of their pathologies during the period of follow up. However, one tenth of the patients each, experienced urethral injury and temporary urinary incontinence. Conclusion: In resource poor settings where the necessary facilities are not available, Foley catheter balloon avulsion of posterior urethral valve is a simple and effective modality of treatment.
{"title":"Foley's Catheter Balloon Avulsion of Posterior Urethral Valve in Children: How Effective?","authors":"C. Emeka","doi":"10.23880/ijsst-16000178","DOIUrl":"https://doi.org/10.23880/ijsst-16000178","url":null,"abstract":"Background: Endoscopic ablation under direct vision is the gold standard for treatment of posterior urethral valve. However, when the facilities are not available, Foley’s catheter balloon avulsion of the valve suffices. The aim of this study was to evaluate the initial outcome of management of children with posterior urethral valve treated by Foley’s catheter balloon avulsion. Materials and Methods: This was a retrospective study of children, aged 15 years and younger, who were treated for posterior urethral valves at the pediatric surgery unit of a teaching hospital in Enugu, Nigeria. The parameters evaluated included the age of the patient at presentation, duration of symptoms before presentation, time interval between presentation and intervention, presenting symptoms, procedure performed, post-intervention complications, duration of hospital stay and outcome of treatment. Results: A total of 24 children underwent catheter balloon avulsion during the study period. The mean age of the patients at presentation was 18 months and the mean duration of hospital stay was 18 days. Poor urinary stream and overflow incontinence were the most common presentations of the patients. Twenty-three out of 24 (96%) patients achieved full recovery with marked improvements in urinary stream and resolution of urinary symptoms. Patients who had hydronephrosis and vesicoureteric reflux before treatment, had resolutions of their pathologies during the period of follow up. However, one tenth of the patients each, experienced urethral injury and temporary urinary incontinence. Conclusion: In resource poor settings where the necessary facilities are not available, Foley catheter balloon avulsion of posterior urethral valve is a simple and effective modality of treatment.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122856630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: A sudden massive hemothorax as the initial manifestation of delayed diagnosis of blunt occult diaphragmatic injuries is extremely rare. We report our experience with two cases of sudden massive thoracic hemorrhage treated surgically for occult blunt diaphragm injury. In the present study, we aimed to present the successful rescue of two cases of sudden massive thoracic hemorrhage due to occult blunt diaphragmatic injury during hospitalization by surgical treatment. Sudden massive hemothorax a few days after hospitalization as an initial manifestation of blunt mysterious diaphragm injury is extremely rare.
{"title":"Surgical Management of Sudden Intrathoracic Hemorrhage in Two Patients with Occult Diaphragmatic Injury and Rib Fracture","authors":"Shouqiang Yu","doi":"10.23880/ijsst-16000180","DOIUrl":"https://doi.org/10.23880/ijsst-16000180","url":null,"abstract":"Background: A sudden massive hemothorax as the initial manifestation of delayed diagnosis of blunt occult diaphragmatic injuries is extremely rare. We report our experience with two cases of sudden massive thoracic hemorrhage treated surgically for occult blunt diaphragm injury. In the present study, we aimed to present the successful rescue of two cases of sudden massive thoracic hemorrhage due to occult blunt diaphragmatic injury during hospitalization by surgical treatment. Sudden massive hemothorax a few days after hospitalization as an initial manifestation of blunt mysterious diaphragm injury is extremely rare.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132838968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parapharyngeal space is a potential deep neck space extending between skull base and the hyoid bone. It is considered to be a rare site for neoplasms and it is even unusual to see Lipomas presenting in this space. Due to the proximity to skull base and presence of important structures in this space, surgical intervention can be complicated. An extensive literature review was carried out to comprehend the presenting features and management of this rare entity. Thirty-six reports/series were included presenting 37 patients between 15-83 years of age with a peak in 5th decade having lipoma in the parapharyngeal space/skull base region. The dimensions of these benign entities ranged between 3 cm to 16 cm. We present & discuss our experience with a large lipoma traversing parotid, submandibular and parapharyngeal spaces and its surgical management. We hope that this review and surgical principles presented will be helpful to the trainees and surgeons dealing with these entities.
{"title":"Parapharyngeal Lipomas: A Literature Review and Surgical Management","authors":"Patrick J. Hesketh","doi":"10.23880/ijsst-16000162","DOIUrl":"https://doi.org/10.23880/ijsst-16000162","url":null,"abstract":"Parapharyngeal space is a potential deep neck space extending between skull base and the hyoid bone. It is considered to be a rare site for neoplasms and it is even unusual to see Lipomas presenting in this space. Due to the proximity to skull base and presence of important structures in this space, surgical intervention can be complicated. An extensive literature review was carried out to comprehend the presenting features and management of this rare entity. Thirty-six reports/series were included presenting 37 patients between 15-83 years of age with a peak in 5th decade having lipoma in the parapharyngeal space/skull base region. The dimensions of these benign entities ranged between 3 cm to 16 cm. We present & discuss our experience with a large lipoma traversing parotid, submandibular and parapharyngeal spaces and its surgical management. We hope that this review and surgical principles presented will be helpful to the trainees and surgeons dealing with these entities.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125984785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fibroadenoma is the most common benign fibroepithelial lesion of the breast in young women, accounting for around 90% of solid lesions of the gland in adolescence. However, juvenile giant fibroadenoma is a rare breast condition that occurs in women under 18 years of age. Due to the similarity of the characteristics of juvenile giant fibroadenoma and phyllodes tumor, both lesions characterized by rapid growth, it is important to establish the differential diagnosis of both pathologies when one of them is suspected, in order to guarantee the most appropriate therapeutic attitude to follow. A 14-year-old woman with no family or personal history of interest, who consulted due to a clinical picture characterized by breast asymmetry secondary to progressive growth of the left breast of 5 months of evolution. An ultrasound-guided core needle biopsy was performed that reported giant juvenile fibroadenoma. Lumpectomy was performed. Histopathological diagnosis compatible with juvenile giant fibroadenoma of the left breast. Based on our case and on the reviewed bibliography, we recommend an early differential diagnosis, as well as an accurate one, and surgical treatment of cases of juvenile giant fibroadenoma. The surgical tactics and technique depend on the age at the time of diagnosis, the clinical and imaging characteristics of the mammary gland and the tumor, as well as the wishes of the patient in question.
{"title":"Juvenile Giant Fibroadenoma Vs. Phyllodes Tumor: Know the Difference in a 14-Years-Old Woman: Case Report","authors":"Padron S Johnny A","doi":"10.23880/ijsst-16000174","DOIUrl":"https://doi.org/10.23880/ijsst-16000174","url":null,"abstract":"Fibroadenoma is the most common benign fibroepithelial lesion of the breast in young women, accounting for around 90% of solid lesions of the gland in adolescence. However, juvenile giant fibroadenoma is a rare breast condition that occurs in women under 18 years of age. Due to the similarity of the characteristics of juvenile giant fibroadenoma and phyllodes tumor, both lesions characterized by rapid growth, it is important to establish the differential diagnosis of both pathologies when one of them is suspected, in order to guarantee the most appropriate therapeutic attitude to follow. A 14-year-old woman with no family or personal history of interest, who consulted due to a clinical picture characterized by breast asymmetry secondary to progressive growth of the left breast of 5 months of evolution. An ultrasound-guided core needle biopsy was performed that reported giant juvenile fibroadenoma. Lumpectomy was performed. Histopathological diagnosis compatible with juvenile giant fibroadenoma of the left breast. Based on our case and on the reviewed bibliography, we recommend an early differential diagnosis, as well as an accurate one, and surgical treatment of cases of juvenile giant fibroadenoma. The surgical tactics and technique depend on the age at the time of diagnosis, the clinical and imaging characteristics of the mammary gland and the tumor, as well as the wishes of the patient in question.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114803184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in lowgrade and high-grade gliomas. However, the diagnostic criteria, in particular for gliomas, are highly various. The aim of our study was to establish genetic profiles for mutation and calcification of diffuse gliomas and to evaluate their predictive factors. Methods: We estimate the different clinical and molecular characterization between IDH1, IDH2 mutant gliomas, p53, ATRX and 1p19q. In addition, whole-transcriptome sequencing and DNA extraction data were used to evaluate the distribution of genetic changes in IDH1 and IDH2 mutant gliomas in a Iranian high grade glioma. Results: Between 2016-2019, among 53 gliomas in our study, 29 cases (54.7% %) harbored an IDH1,2 mutation, 21 cases (39.6 %) harbored an p53 mutation and 19 cases (35.8 %) harbored an ATRX. In addition, 1p19q co-deletion mutation was found in 7 cases (12.2%). We found that IDH1 and IDH2 are mutually entirely in gliomas. There was no significant relation between histopathology, tumor location and clinical finding with diagnosed mutations. Conclusion: Our study discloses an associated distinction between IDH1 and IDH2 mutant gliomas nearly in half of patients, followed by p53. These mutations should be reviewed separately because their differences could have indication for the diagnosis and treatment of IDH1/2 mutant gliomas.
{"title":"Epidemiological Study of Molecular and Genetic Classification in Adult Diffuse Glioma","authors":"M. Faraji-Rad","doi":"10.23880/ijsst-16000171","DOIUrl":"https://doi.org/10.23880/ijsst-16000171","url":null,"abstract":"Background: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in lowgrade and high-grade gliomas. However, the diagnostic criteria, in particular for gliomas, are highly various. The aim of our study was to establish genetic profiles for mutation and calcification of diffuse gliomas and to evaluate their predictive factors. Methods: We estimate the different clinical and molecular characterization between IDH1, IDH2 mutant gliomas, p53, ATRX and 1p19q. In addition, whole-transcriptome sequencing and DNA extraction data were used to evaluate the distribution of genetic changes in IDH1 and IDH2 mutant gliomas in a Iranian high grade glioma. Results: Between 2016-2019, among 53 gliomas in our study, 29 cases (54.7% %) harbored an IDH1,2 mutation, 21 cases (39.6 %) harbored an p53 mutation and 19 cases (35.8 %) harbored an ATRX. In addition, 1p19q co-deletion mutation was found in 7 cases (12.2%). We found that IDH1 and IDH2 are mutually entirely in gliomas. There was no significant relation between histopathology, tumor location and clinical finding with diagnosed mutations. Conclusion: Our study discloses an associated distinction between IDH1 and IDH2 mutant gliomas nearly in half of patients, followed by p53. These mutations should be reviewed separately because their differences could have indication for the diagnosis and treatment of IDH1/2 mutant gliomas.","PeriodicalId":370833,"journal":{"name":"International Journal of Surgery & Surgical Techniques","volume":"144 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115362754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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