DNA序列中近似串联重复序列的优化算法

Sheng Li, Q. Jiang, Dan Wei
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引用次数: 2

摘要

在基因分析中,在DNA序列中寻找近似串联重复序列是一个重要问题。MSATR是一种最新的重复搜索方法,存在运行成本高、结果质量差的缺点。为了更有效地检测基因组序列中近似串联重复序列,提出了一种优化的mMSATR算法。mMSATR通过引入CASM的定义来缩小搜索范围,优化MSATR采用的原有机制,提高了检测过程的效率,提高了结果质量。理论分析和实验结果表明,mMSATR能够在更短的运行时间内获得更多的结果。mMSATR算法在查找结果方面优于其他方法,并且大大降低了运行时成本,这在基因数据变大时是有利的。
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An Optimized Algorithm for Finding Approximate Tandem Repeats in DNA Sequences
In gene analysis, finding approximate tandem repeats in DNA sequence is an important issue. MSATR is one of the latest methods for finding those repetitions, which suffers deficiencies of runtime cost and poor result quality. This paper proposes an optimized algorithm mMSATR for detecting approximate tandem repeats in genomic sequences more efficiently. By introducing the definition of CASM to reduce the searching scope and optimizing the original mechanism adopted by MSATR, mMSATR makes the detecting process more efficient and improves the result quality. The theoretical analysis and experiment results indicates that mMSATR is able to get more results within less runtime. Algorithm mMSATR is superior to other methods in finding results, and it greatly reduces the runtime cost, which is of benefit when the gene data becomes larger.
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