用接触球镜片改进手机显微镜成像

Grant W. Bidney, A. Brettin, B. Jin, N. Limberopoulos, I. Anisimov, Hanyang Li, A. Maslov, V. Astratov
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引用次数: 1

摘要

结果表明,利用折射率n=1.85的毫米级球透镜与以染料掺杂微球为代表的荧光(FL)物体接触,可以提高手机显微镜的分辨率。通过球透镜进行虚拟成像,在约0.1 × 0.1 mm2的视场范围内,分辨率从~35µm提高到~2µm。通过优化接触球透镜的参数,可以期望进一步提高分辨率和视场,从而使所提出的技术在移动生物医学成像中得到广泛应用。
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Improving Cellphone Microscopy Imaging with Contact Ball Lenses
It is shown that the resolution of cellphone-based microscopy can be improved with the use of millimeter-scale ball lenses with index n=1.85 placed in contact with fluorescent (FL) objects represented by dye-doped microspheres. Using the virtual imaging through such ball lenses, the resolution improvement from ~35 µm to ~2 µm is achieved over a field-of-view of about 0.1 × 0.1 mm2. Further improvement of resolution and field-of-view can be expected with optimization of parameters of the contact ball lenses that can lead to wide applications of the proposed technology in mobile biomedical imaging.
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