经皮留置引流治疗晚期肿瘤复发性腹水的安全性和有效性

Kwonoh Park, Geongsil Lee, Jae-Joon Kim, Sang-Bo Oh, S. Oh, E. Park, J. Kim, J. Jang, U. Jeon
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摘要

目的:临终关怀姑息疗护病房的晚期癌症患者因凝血功能障碍、表现或病情不佳而不愿进行重复性侵入性手术,而住院期间定期冲洗等导管管理容易。本研究的目的是探讨腹腔留置导尿管(IP)在住院晚期癌症复发性腹水患者中的安全性和有效性。方法:回顾性分析2016年8月至2018年6月在釜山国立大学梁山医院安宁疗护病房接受IP导管治疗的患者。所有导管均由介入放射科医师在放射学指导下插入。主要终点是功能性IP导管维持率,即导管保持通畅引流至预定时间。结果:在研究期间,共有25例晚期癌症患者接受了IP导管置入。所有导管均顺利插入,无重大并发症,但一名患者有轻微出血,另一名患者有暂时疼痛。从入院到置管的中位时间为5天(范围1 ~ 49天)。21例导管维持功能至预定时间,3例维持功能不全,最后1例因梗阻及疼痛提前拔除。最后,功能性IP维持率为84%(21/25),导管功能寿命中位数为15天(95%可信区间10.8 ~ 17.2)。结论:我们的研究显示,在住院晚期癌症合并恶性腹水患者中,IP导管维持的效果和安全性相对较好。(梨花医学杂志2020;43(2):29-34)
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Safety and Effectiveness of Indwelling Percutaneous Drainage in Hospitalized Terminally Ill Cancer Patients with Recurrent Ascites
Objectives: Terminally ill cancer patients in hospice palliative care unit are reluctant to undergo repetitive invasive procedures due to coagulopathies and poor performance or condition, while catheter management such as regular irrigation during hospitalization is easy. The purpose of this study was to investigate the safety and efficacy of indwelling intraperitoneal (IP) catheter in hospitalized terminally ill cancer patients with recurrent ascites. Methods: A retrospective review was conducted in patients who underwent IP catheter at the hospice palliative care unit of Pusan National University Yangsan Hospital between August 2016 and June 2018. All catheters were inserted by interventional radi-ologists with radiological guidance. The primary end-points were functional IP catheter maintenance rate, which is catheter maintained with patency for drainage until the intended time. Results: A total of 25 terminally ill cancer patients underwent IP catheters placements during the study period. All catheters were successfully inserted without major complications, but one patient had trivial bleeding and one other patient had temporary pain. The median time from admission to catheter insertion was 5 days (range, 1 to 49 days). Twenty-one catheters were maintained with function until the intended time, three cases were maintained without function, and the last one was removed early due to obstruction and pain. Finally, the functional IP maintenance rate was 84% (21/25) and the median functional catheter life span was 15 days (95% confidence interval, 10.8 to 17.2). Conclusion: Our study showed relatively favorable results for IP catheter maintenance and safety in hospitalized terminally ill cancer patients with malignant ascites. (Ewha Med J 2020;43(2):29-34)
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