{"title":"Sex differences in pharmacotherapy for heart failure","authors":"I. Cho","doi":"10.12771/emj.2024.e3","DOIUrl":"https://doi.org/10.12771/emj.2024.e3","url":null,"abstract":",","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"317 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140470878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sleep disorders, sleep quality, and health-related quality of life in\u0000 patients with cancer in Turkey: a multi-center cross-sectional\u0000 survey","authors":"Vesile Şenol, Zekeriya Temircan","doi":"10.12771/emj.2024.e5","DOIUrl":"https://doi.org/10.12771/emj.2024.e5","url":null,"abstract":"","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"98 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140479597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heather Van Epps, Olaya Astudillo, Yaiza Del Pozo Martín, Joan Marsh
{"title":"The Sex and Gender Equity in Research (SAGER) guidelines:\u0000 implementation and checklist development: a Korean translation","authors":"Heather Van Epps, Olaya Astudillo, Yaiza Del Pozo Martín, Joan Marsh","doi":"10.12771/emj.2024.e11","DOIUrl":"https://doi.org/10.12771/emj.2024.e11","url":null,"abstract":"","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"33 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140479240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gender equity in medical journals in Korea and this issue","authors":"Sun Huh","doi":"10.12771/emj.2024.e1","DOIUrl":"https://doi.org/10.12771/emj.2024.e1","url":null,"abstract":"","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"354 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140470618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shirin Heidari, Tom Babor, Paola De Castro, Sera Tort, M. Curno
{"title":"Sex and Gender Equity in Research (SAGER): rationale for the SAGER\u0000 guidelines and recommended use: a Korean translation","authors":"Shirin Heidari, Tom Babor, Paola De Castro, Sera Tort, M. Curno","doi":"10.12771/emj.2024.e10","DOIUrl":"https://doi.org/10.12771/emj.2024.e10","url":null,"abstract":"","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"385 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140471845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Overview of endocrine tumor syndromes manifesting as adrenal tumors","authors":"Ja Hye Kim","doi":"10.12771/emj.2024.e4","DOIUrl":"https://doi.org/10.12771/emj.2024.e4","url":null,"abstract":"originating from the adrenal glands","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140479222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: Blood and urine are commonly used specimens for clinical testing, and their contents, particularly exosomal microRNA (miRNA), are diverse, reflecting the metabolic activities of tissues and organs in the body. Methods: Blood and urine samples were collected from six healthy adults. Exosomes were then enriched from these samples, followed by sequencing and bioinformatic analysis of exosomal miRNA. Results: The comparative analysis of miRNAs in blood and urine revealed that 41 miRNAs were more abundant in blood, while 61 were found at lower levels. Notably, hsa-miR-934 was among those with higher expression in blood, whereas hsa-miR-425-5p was one of the miRNAs with lower expression. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that the target mRNAs of differentially expressed exosomal miRNAs (DEexo-miRNAs) in both blood and urine are implicated in various signaling pathways, including proteoglycans in cancer, axonal guidance, and the regulation of the actin cytoskeleton. Additionally, the target mRNAs associated with DEexo-miRNAs in urine were also linked to processes such as ubiquitin-mediated proteolysis and the phosphatidylinositol signaling system. In contrast, the target mRNAs corresponding to DEexo-miRNAs in blood were involved in the FoxO signaling pathway and chronic myeloid leukemia, among others. Conclusion: This study observed differential expression of exosomal miRNAs in blood and urine, thereby enriching the available library of exosomal miRNA for these two sample types. It also lays the groundwork for the detection of exosomal biomarkers from blood and urine.
{"title":"Exosomal microRNAs (miRNAs) in blood and urine under physiological conditions: a comparative study","authors":"Chun-yan Lv, Zhong Yuan, Hu Yao","doi":"10.12771/emj.2024.e6","DOIUrl":"https://doi.org/10.12771/emj.2024.e6","url":null,"abstract":"Objectives: Blood and urine are commonly used specimens for clinical testing, and their contents, particularly exosomal microRNA (miRNA), are diverse, reflecting the metabolic activities of tissues and organs in the body. Methods: Blood and urine samples were collected from six healthy adults. Exosomes were then enriched from these samples, followed by sequencing and bioinformatic analysis of exosomal miRNA. Results: The comparative analysis of miRNAs in blood and urine revealed that 41 miRNAs were more abundant in blood, while 61 were found at lower levels. Notably, hsa-miR-934 was among those with higher expression in blood, whereas hsa-miR-425-5p was one of the miRNAs with lower expression. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated that the target mRNAs of differentially expressed exosomal miRNAs (DEexo-miRNAs) in both blood and urine are implicated in various signaling pathways, including proteoglycans in cancer, axonal guidance, and the regulation of the actin cytoskeleton. Additionally, the target mRNAs associated with DEexo-miRNAs in urine were also linked to processes such as ubiquitin-mediated proteolysis and the phosphatidylinositol signaling system. In contrast, the target mRNAs corresponding to DEexo-miRNAs in blood were involved in the FoxO signaling pathway and chronic myeloid leukemia, among others. Conclusion: This study observed differential expression of exosomal miRNAs in blood and urine, thereby enriching the available library of exosomal miRNA for these two sample types. It also lays the groundwork for the detection of exosomal biomarkers from blood and urine.","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"368 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140473339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Conventional open thyroidectomy is a safe procedure, but it has the disadvantage of leaving noticeable scars on the neck. Bilateral axillo-breast approach (BABA) robotic thyroidectomy was developed as an alternative technique to remove thyroid glands without making incisions in the neck. In traditional BABA robotic thyroidectomy, dividing the isthmus is a routine step to improve the efficiency of the dissection during thyroid surgery. However, there are safety concerns when performing this procedure on patients with thyroid cancer located in the isthmus. We report a case of BABA robotic total thyroidectomy carried out without dividing the isthmus in a patient with isthmic papillary thyroid carcinoma. Our experience suggests that BABA robotic surgery can be a feasible and safe option for selected patients with isthmic papillary thyroid carcinoma.
传统的开放式甲状腺切除术是一种安全的手术，但其缺点是会在颈部留下明显的疤痕。双侧腋窝-乳房入路（BABA）机器人甲状腺切除术是一种无需在颈部开刀即可切除甲状腺的替代技术。在传统的 BABA 机器人甲状腺切除术中，分割峡部是提高甲状腺手术解剖效率的常规步骤。然而，对位于峡部的甲状腺癌患者实施该手术存在安全隐患。我们报告了一例在不分割峡部的情况下为峡部甲状腺乳头状癌患者实施 BABA 机器人甲状腺全切除术的病例。我们的经验表明，对于选定的峡部甲状腺乳头状癌患者来说，BABA机器人手术是一种可行且安全的选择。
{"title":"Bilateral axillo-breast approach robotic total thyroidectomy without isthmectomy: a case report","authors":"Hyeji Kim, Hyeonuk Hwang, H. Kwon","doi":"10.12771/emj.2024.e7","DOIUrl":"https://doi.org/10.12771/emj.2024.e7","url":null,"abstract":"Conventional open thyroidectomy is a safe procedure, but it has the disadvantage of leaving noticeable scars on the neck. Bilateral axillo-breast approach (BABA) robotic thyroidectomy was developed as an alternative technique to remove thyroid glands without making incisions in the neck. In traditional BABA robotic thyroidectomy, dividing the isthmus is a routine step to improve the efficiency of the dissection during thyroid surgery. However, there are safety concerns when performing this procedure on patients with thyroid cancer located in the isthmus. We report a case of BABA robotic total thyroidectomy carried out without dividing the isthmus in a patient with isthmic papillary thyroid carcinoma. Our experience suggests that BABA robotic surgery can be a feasible and safe option for selected patients with isthmic papillary thyroid carcinoma.","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140478851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 51-year-old man presented with multiple inflammatory skin lesions on both lower legs that had developed 3 weeks prior. He had a 15-year history of gout and stage 3 chronic kidney disease. Upon physical examination, multiple yellowish, firm papulonodules with evidence of suppuration were noted on his shins, calves, knees, and ankles (Fig. 1). A skin biopsy revealed well-circumscribed deposits of pinkish, amorphous material in the deep dermis, surrounded by histiocytic infiltration and a fibrous reaction. Von Kossa staining did not show any calcium deposition (Fig. 2). The patient was diagnosed with disseminated cutaneous gout, and the skin lesions were treated symptomatically with topical steroids and oral antihistamines. Gout is a chronic disease characterized by the deposition of monosodium urate (MSU) crystals, which form when urate concentrations are elevated [1]. These MSU crystals can accumulate in joints, bones, and various body tissues, including the skin and soft tissues. The disease can be
{"title":"Disseminated cutaneous gout: a rare manifestation of gout","authors":"Yoon Jin Choi, J. Byun, You Won Choi, H. Choi","doi":"10.12771/emj.2024.e9","DOIUrl":"https://doi.org/10.12771/emj.2024.e9","url":null,"abstract":"A 51-year-old man presented with multiple inflammatory skin lesions on both lower legs that had developed 3 weeks prior. He had a 15-year history of gout and stage 3 chronic kidney disease. Upon physical examination, multiple yellowish, firm papulonodules with evidence of suppuration were noted on his shins, calves, knees, and ankles (Fig. 1). A skin biopsy revealed well-circumscribed deposits of pinkish, amorphous material in the deep dermis, surrounded by histiocytic infiltration and a fibrous reaction. Von Kossa staining did not show any calcium deposition (Fig. 2). The patient was diagnosed with disseminated cutaneous gout, and the skin lesions were treated symptomatically with topical steroids and oral antihistamines. Gout is a chronic disease characterized by the deposition of monosodium urate (MSU) crystals, which form when urate concentrations are elevated [1]. These MSU crystals can accumulate in joints, bones, and various body tissues, including the skin and soft tissues. The disease can be","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"212 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140472606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dong Chan Joo, Gwang Ha Kim, B. Lee, M. Lee, Cheolung Kim
Subepithelial tumors in the upper gastrointestinal (GI) tract are often detected during nationwide endoscopic gastric cancer screening in Korea. Most GI lipomas are asymptomatic and do not necessitate further treatment. However, large tumors may lead to complications such as bowel obstruction, intussusception, and bleeding. These GI lipomas require endoscopic or surgical resection. On radiological examination, GI lipomas typically manifest as hypodense lesions with similar density to that of fat tissue. White-light endoscopy generally reveals a yellowish subepithelial tumor exhibiting a positive cushion sign, while endoscopic ultrasonography shows a homogeneous hypoechoic mass within the third layer of the GI tract. We present the case of an 81-year-old woman with symptomatic duodenal lipoma following endoscopic resection.
{"title":"Endoscopically resected duodenal lipoma as an uncommon cause of upper gastrointestinal bleeding: a case report","authors":"Dong Chan Joo, Gwang Ha Kim, B. Lee, M. Lee, Cheolung Kim","doi":"10.12771/emj.2024.e8","DOIUrl":"https://doi.org/10.12771/emj.2024.e8","url":null,"abstract":"Subepithelial tumors in the upper gastrointestinal (GI) tract are often detected during nationwide endoscopic gastric cancer screening in Korea. Most GI lipomas are asymptomatic and do not necessitate further treatment. However, large tumors may lead to complications such as bowel obstruction, intussusception, and bleeding. These GI lipomas require endoscopic or surgical resection. On radiological examination, GI lipomas typically manifest as hypodense lesions with similar density to that of fat tissue. White-light endoscopy generally reveals a yellowish subepithelial tumor exhibiting a positive cushion sign, while endoscopic ultrasonography shows a homogeneous hypoechoic mass within the third layer of the GI tract. We present the case of an 81-year-old woman with symptomatic duodenal lipoma following endoscopic resection.","PeriodicalId":197820,"journal":{"name":"The Ewha Medical Journal","volume":"617 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140472306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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