细菌尿和白细胞尿诊断0-12月龄尿路感染的临界值

Rahmania Chandra Savitri, D. Ariningrum, Y. Mashuri
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引用次数: 0

摘要

尿路感染(uti)是社区最常见的细菌感染之一,包括婴儿和儿童。尿培养是检测尿路感染的金标准方法,但它昂贵、不实用且耗时长。目前,自动化尿液分析方法已被许多人用于UTI筛查。本研究的目的是利用自动尿分析仪Sysmex UX-2000,采用流式细胞术(FCM)方法确定白细胞尿和细菌尿的临界值,用于筛查0-12个月的婴儿尿路感染。2019年8月至10月,在泗水的Moewardi医生医院进行了一项带有诊断测试的横断面研究。34例患者采用Sysmex UX-2000进行尿液培养检查和自动尿液分析仪。根据ROC曲线确定白细胞尿和细菌尿的临界值,然后测定敏感性、特异性、阳性预测值(PPV)、阴性预测值(NPV)、准确性和似然比。0-12月龄婴幼儿白细胞尿的临界值为46.2个细胞/μL,敏感性88%,特异性68%,PPV 50%, NPV 94%,准确率73%,似然比2.77。0 ~ 12月龄婴幼儿细菌尿的临界值为247.6个细胞/μL,敏感性66%,特异性64%,PPV 40%, NPV 84%,准确率64%,似然比1.85。使用自动尿液分析仪Sysmex UX-2000检测白细胞尿和细菌尿的临界值阴性预测值(NPV) >80%,可用于0-12月龄婴幼儿尿路感染筛查。
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Cut-off Values of Bacteriuria and Leukocyturia to Diagnose Urinary Tract Infection in Patients Aged 0-12 Months
Urinary Tract Infections (UTIs) are among the most common bacterial infections in the community, including infants and children. Urine culture is the gold standard test for UTI detection, but it is expensive, impractical and takes a long time. At present, automated urinalysis methods have been used by many for UTI screening. The aim of this study was to determine the cut-off values of leukocyturia and bacteriuria using flow cytometry (FCM) method using automated urinalyzer Sysmex UX-2000 for screening of UTI in infant patients aged 0-12 months. A cross-sectional study with a diagnostic test was conducted at the Dr. Moewardi Hospital in Surakarta on August - October 2019. A total of 34 patients underwent urine culture examination and automatic urine analyzer using Sysmex UX-2000. Cut-off values of leukocyturia and bacteriuria were determined from the ROC curve followed by determination of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy and likelihood ratio. The cut-off value for leukocyturia in infant patients aged 0-12 months was 46.2 cells/μL with a sensitivity value of 88%, specificity 68%, PPV 50%, NPV 94%, accuracy 73% and likelihood ratio 2.77. The cut-off value of bacteriuria in infant patients aged 0-12 months was 247.6 cells/μL with a sensitivity value of 66%, specificity 64%, PPV 40%, NPV 84%, accuracy 64% and likelihood ratio 1.85. Cut-off values of leukocyturia and bacteriuria using automatic urine analyzer Sysmex UX-2000 with negative predictive value (NPV) >80% can be used for UTI screening in infant patients aged 0-12 months.
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