肺动脉导管与中心静脉导管在心脏搏动冠状动脉搭桥手术中的应用:一种比较方法

P. Desai, S. Mahure, M. Sarkar, Sanjeeta R Umbarkar
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引用次数: 0

摘要

背景:中心静脉和肺动脉导管是冠状动脉旁路移植术中血流动力学监测的重要组成部分。方法:本前瞻性随机试验将60例患者平均分为两组,分别在大剂量阿片类药物和泮库溴铵诱导麻醉后接受中心静脉或肺动脉导管插管。年龄在35-65岁、射血分数40-60%、接受非体外循环冠状动脉搭桥手术的患者被纳入研究,而有左心室功能障碍的患者被排除在外。所有患者均由同一组外科医生进行手术。围手术期通过扩液和肌力支持使收缩压(SBP)和/或平均动脉压(MAP)分别保持在90和60 mm Hg以上。硝酸甘油用于血压控制和冠状动脉舒张。比较两组患者对肌力的干预需求、持续时间、ICU住院时间和并发症发生情况。结果:CVP组患者开始使用肌力药物的比例明显高于PAC组(66.6% vs 40%, P=0.038)。其中,75%的A组需要的补液时间少于24小时,而65%的b组需要类似的补液试验[40%对53.33%;P=0.30],重症监护病房停留时间相似(大于48小时)[66.67% vs 53.3%;P =0.29,卡方检验]。CVP组出现并发症的患者较多[6.6 vs 16.6%;P = 0.22)。每组均有1例患者死亡。结论:在保留左室功能的患者进行OPCAB手术时,PA导管引导管理并不比单独CVP引导管理提供额外的益处。
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Pulmonary Artery Catheter Versus Central Venous Catheter in Patients Undergoing Beating Heart Coronary Artery Bypass Surgery: A Comparative Approach
Background: Central venous and pulmonary artery catheter are integral part of hemodynamic monitoring during off pump coronary artery bypass grafting surgery. Methods: In this prospective randomized trial, sixty patients were divided equally into two groups, to receive either central venous or pulmonary artery catheter after induction of anesthesia with high dose of opioid and Inj pancuronium. Patients between 35-65 years with ejection fraction 40-60% undergoing elective off pump coronary artery bypass surgery were included while those with left ventricular dysfunction were excluded. All patients were operated by same team of surgeons. Systolic blood pressure (SBP) and/or mean arterial pressure (MAP) was kept above 90 and 60 mm Hg respectively throughout perioperative period by fluid volume expansion and inotropic support. Nitroglycerine was used for blood pressure control and coronary vasodilation. Both groups were compared with respect to intervention requiring inotropes and its duration, ICU stay and any complications occurred. Results: Significant number of patients in CVP group were started on inotropes than PAC group (66.6% vs 40%, P=0.038). Among these, 75% in Gr. A needed it for less than 24 hours compared to 65% in Gr. B. Both groups needed similar trials of fluid challenge [40% vs 53.33%; P=0.30] and showed similar duration of intensive care unit stay (more than 48 hrs) [66.67% vs 53.3%; p=0.29, chi square test]. More number of patients developed complications in CVP group [6.6 vs 16.6%; P=0.22]. One patient in each group had mortality. Conclusion: PA catheter guided management does not provide additional benefit over CVP guided management alone during OPCAB surgery in patients with preserved LV function.
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