Synergism from combination of platinums in ovarian cancer

The present study shows that combinations of cisplatin and YH12 produce sequence- and concentration-dependent synergism in human ovarian cancer cell lines A2780 and A2780cisR. Addition of YH12 followed by cisplatin 4 h later or addition of the two compounds at the same time produces synergism whereas the addition of cisplatin first followed by YH12 4 h later results into antagonism. If the results are found to be true in vivo, they may have profound implication in the design of combination therapy.