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2009 International Conference on Biomedical and Pharmaceutical Engineering最新文献

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Noise reduction in DEXA image based on system noise modeling 基于系统噪声建模的DEXA图像降噪方法
Pub Date : 2009-12-02 DOI: 10.1109/ICBPE.2009.5384080
J. Kwon, S. Cho, Y. Ahn, Yong Man Ro
Denoising X-ray image is an important preprocessing process to measure BMD (Bone Mineral Density) correctly. In this paper, we deal with denoising X-ray image in DEXA (Dual-Energy X-ray Absorptiometry) system. Image noise in DEXA is modeled by separating source and detector noises. Using the noise model in DEXA, a noise reduction method is proposed. The proposed denoising method consists of Wiener filter to reduce the detector noise, and logarithmic scale-wavelet BayesShrink filter to reduce the source noise. Experimental results verified the proposed DEXA noise model and showed that the proposed noise reduction method outperformed the conventional method.
x射线图像去噪是正确测量骨密度的重要预处理过程。本文研究了双能x射线吸收测量系统中x射线图像的去噪问题。DEXA中的图像噪声是通过分离源噪声和检测器噪声来建模的。利用DEXA中的噪声模型,提出了一种降噪方法。该方法采用维纳滤波降低检测器噪声,对数尺度-小波贝叶斯收缩滤波降低源噪声。实验结果验证了所提出的DEXA噪声模型,并表明所提出的降噪方法优于传统降噪方法。
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引用次数: 12
Analysis of a novel magnetic stimulation system: Magnetic harmonic multi-cycle stimulation (MHMS) 一种新型磁刺激系统:磁谐波多周期刺激(MHMS)分析
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384111
S. Goetz, T. Weyh, H. Herzog
Magnetic stimulation is nowadays a standard instrument in research as well as clinical applications. But available systems still have some vital problems; these include the extreme energetic ineffectiveness and the poor flexibility of stimulation properties. In the following text we analyse a new degree of freedom for stimulation devices in the time domain. This approach owes its high potential from the simplicity to implement this feature in existing commercial systems. A similar principle has already been applied for a stimulation device long time ago, but was intentionally overdamped to mimic a monophasic system and therefore energetically meaningless. For the current work, the alternative design was implemented into a sophisticated simulation model to predict its properties. A substantial benefit is for instance the feasibility to lower the threshold of the required current within the stimulation coil for creating nervous action potentials dramatically. Accordingly, the energetic impact with its even quadratic relation to the amplitude and especially the reduction of the coil heating are remarkable. The opportunity to control the nervous reaction more precisely and to gain access to the field of more complex spiking patterns is another special attribute. The realization of the concept seems reasonably simple, whereas the impact was found to be enormous. But this shall not block the view of the fact that the discovery and the explanation needs a change of thinking about the stimulating effect of inductive stimulation.
磁刺激如今已成为研究和临床应用的标准手段。但现有的系统仍然存在一些重大问题;这些包括极端的能量无效和刺激特性的灵活性差。在接下来的文本中,我们分析了一种新的时域刺激装置的自由度。由于在现有商业系统中实现该特性的简单性,该方法具有很高的潜力。很久以前,一个类似的原理已经应用于一个刺激装置,但被故意过阻尼以模拟单相系统,因此在能量上毫无意义。对于目前的工作,替代设计被实现到一个复杂的仿真模型中,以预测其性能。一个实质性的好处是,例如,降低刺激线圈内产生神经动作电位所需电流的阈值的可行性。因此,能量影响与振幅呈均匀二次关系,特别是线圈加热的减少是显著的。更精确地控制神经反应和进入更复杂的峰值模式领域的机会是另一个特殊的属性。这个概念的实现似乎相当简单,然而人们发现它的影响是巨大的。但这并不妨碍这样一个事实,即发现和解释需要改变对归纳刺激的刺激作用的思考。
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引用次数: 3
Photosensitizing drugs loaded stable carrier-artificial oil bodies 负载稳定载体-人工油体的光敏药物
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384067
Yu-Chi Chiou, P. Lai
The photosensitizer mTHPC was loaded in oil body which significantly enhanced the nuclear localization of mTHPC in comparison to load in F68 micelle. Furthermore, in this study, the mTHPC was discovered in cellular nucleus of HeLa cells which were treated about 1 h. As the results, the cells treaded by mTHPC-loaded in oil body with light showed that the efficacy of PDT has better than F68 micelle, because the oil body enhanced the nuclear accumulation of mTHPC. Thus, it is suggest that the oil body held great promise for a PDT carrier in the future.
将光敏剂mTHPC装载在油体中,与装载在F68胶束中相比,显著增强了mTHPC的核定位。此外,在本研究中,在处理约1 h的HeLa细胞细胞核中发现了mTHPC。结果表明,在油体中负载mTHPC的光作用下,PDT的效果优于F68胶束,因为油体增强了mTHPC的核积累。因此,表明油体在未来的PDT载体中具有很大的前景。
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引用次数: 1
Screening of plant Macaranga peltata for its antioxidant, antimicrobial and cytotoxicity activity 植物龙葵抗氧化、抑菌及细胞毒活性的筛选
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384086
M. Verma, P. Raj, H. Chandrasekhar, J. Rao, N. Udupa
The plant Macaranga peltata (Euphorbiaceae) leaves and stem bark was tested for its in vitro antioxidant, antimicrobial and cytotoxicity activity using different methods. In vitro anti oxidant activity Stem Bark extract showed Inhibitory concentration 50 % (IC50) value of 10.13 than the Leaf extract IC50=14.85 for DPPH Assay. Standard Ascorbic acid showed IC50=7.28. For ABTS free radical scavenging activity Leaf extract IC50=7.61 showed better activity than the Stem Bark extract IC50=9.77. Standard anti-oxidant Ascorbic acid showed IC50=11.76. The Nitric Oxide Radical inhibition activity was better shown by Stem Bark extract IC50=573.39 than Leaf extract IC50⇒1000. Whereas IC50 value for the standard anti-oxidant Ascorbic acid was 127.16. Scavenging of Superoxide radical by Alkaline DMSO method i.e. NBT Assay showed better activity for Leaf extract IC50=54.12 than Stem Bark extract IC50=55.52. But both Stem Bark and Leaf extract showed very good activity for NBT Assay and their IC50 values were very close to the Standard anti-oxidant Rutin IC50=49.73. In anti microbial activity MIC for Leaf extract was between 62.5µg/ml to 125µg/ml for Escherichia coli, 125µg/ml to 250µg/ml for Pseudomonas aeruginosa, 62.5µg/ml to 125µg/ml for Bacillus subtilis and 31.25µg/ml to 62.5µg/ml for Staphylococcus aureus. Whereas MIC for Stem Bark extract was between 500µg/ml to 1000µg/ml for Escherichia coli, 250µg/ml to 500µg/ml for Pseudomonas aeruginosa, 62.5µg/ml to 125µg/ml for Bacillus subtilis and 62.5µg/ml to 125µg/ml for Staphylococcus aureus. Ciprofloxacin used as standard antibiotic showed MIC between 1.953 µg/ml to7.813 µg/ml for all four bacterial strains. Cytotoxicity of Macaranga peltata Leaf and Stem Bark extracts was tested on Human Liver Cancer cell line HepG2. Four concentrations (1000µg/ml, 500µg/ml, 250µg/ml and 125µg/ml) of both extract were tested for the activity by MTT assay. Both Leaf and Stem Bark extracts showed very good cytotoxicity activity and their CTC50 value was 51.07 µg/ml and 22.32 µg/ml respectively.
采用不同的方法测定了大胡科植物马龙果叶和茎皮的体外抗氧化、抗菌和细胞毒活性。体外抗氧化活性DPPH实验显示,茎皮提取物的抑制浓度(IC50)值为10.13,而叶提取物的IC50值为14.85。标准抗坏血酸IC50=7.28。在清除ABTS自由基活性方面,叶提取物IC50=7.61优于茎皮提取物IC50=9.77。标准抗坏血酸IC50=11.76。茎皮提取物IC50=573.39比叶提取物IC50=⇒1000抑制一氧化氮自由基活性更好。而标准抗坏血酸的IC50值为127.16。碱性DMSO法(NBT法)对超氧自由基的清除效果表明,叶提取物IC50=54.12的清除效果优于茎皮提取物IC50=55.52的清除效果。而茎皮和叶提取物的抗氧化活性与标准抗氧化剂芦丁的IC50值非常接近,IC50值为49.73。在抗微生物活性方面,叶提取物对大肠杆菌、铜绿假单胞菌、枯草芽孢杆菌和金黄色葡萄球菌的MIC分别为62.5µg/ml ~ 125µg/ml、125µg/ml ~ 250µg/ml和31.25µg/ml ~ 62.5µg/ml。而茎皮提取物的MIC值为大肠杆菌500µg/ml至1000µg/ml,铜绿假单胞菌250µg/ml至500µg/ml,枯草芽孢杆菌62.5µg/ml至125µg/ml,金黄色葡萄球菌62.5µg/ml至125µg/ml。环丙沙星作为标准抗生素,4种菌株的MIC均在1.953µg/ml ~ 7.813µg/ml之间。以人肝癌细胞株HepG2为实验对象,研究了黄芩叶及茎皮提取物的细胞毒性。采用MTT法测定两种提取物在1000µg/ml、500µg/ml、250µg/ml和125µg/ml浓度下的活性。叶皮提取物和茎皮提取物均表现出良好的细胞毒活性,CTC50值分别为51.07µg/ml和22.32µg/ml。
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引用次数: 4
Experimental study on blood flow rate measurement using intravascular catheter 血管内导管测量血流速率的实验研究
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384073
Seng Sing Tan, C. M. Lam, W. E. Lim
Measurement of blood flow rate is essential in assessing the cardiovascular status of patients with coronary artery diseases during treatments. It provides feedback and monitors any improvements in the vascular system after the cardiovascular surgery. This paper presents the latest development of a new approach to measure blood flow rate using a catheter involving the concept of heat exchanger. In the study, an intravascular catheter is inserted into a simulated blood stream and a heat transfer element attached at the distal end extracts a small amount of heat from blood to the cooling fluid in the heat transfer element. We can correlate the blood flow rate to the change of the outlet temperature of the cooling fluid. In this approach, we can determine the cardiac output without the need for introduction of saline solution or other substance into patient body. Unlike Swan-Ganz catheter, it does not alter the blood temperature. Consequently, it is repeatable without any possible adverse effects due to altering blood composition or heating in the vascular system. In this experimental study, we have done the comparison between different designs and settings, and confirmed that this approach has a great potential to be an effective way of measuring blood flow rate as, well as cardiac output.
测量血流速率是评估治疗期间冠心病患者心血管状态的必要条件。它提供反馈和监测心血管手术后血管系统的任何改善。本文介绍了一种利用导管测量血流速率的新方法的最新进展,该方法涉及热交换器的概念。在本研究中,将一根血管内导管插入模拟血流中,末端附着的传热元件将血液中的少量热量提取到传热元件中的冷却流体中。我们可以把血液流速与冷却液出口温度的变化联系起来。在这种方法中,我们可以在不需要向患者体内引入生理盐水或其他物质的情况下测定心输出量。与Swan-Ganz导管不同,它不会改变血液温度。因此,它是可重复的,没有任何可能的不利影响,由于改变血液成分或加热血管系统。在本实验研究中,我们对不同的设计和设置进行了比较,证实了这种方法有很大的潜力成为一种测量血流量和心输出量的有效方法。
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引用次数: 2
Identification of hearing disorder by multi-band entropy cepstrum extraction from infant's cry 婴儿哭声多波段熵倒谱提取识别听力障碍
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384066
Mahmoud Mansouri Jam, H. Sadjedi
Infant's cry is a multimodal behavior that contains a lot of information about the infant, particularly, information about the health of the infant. In this paper a new feature in infant cry analysis is presented for recognition two groups: infants with hearing disorder and normal infants, by Mel frequency multi-band entropy cepstrum extraction from infant's cry. Signal processing stage is included by silence elimination, filtering, pre-emphasizing and feature extraction. After taking Fourier transform, spectral entropy was computed as single feature for all of cry sample. In classifying stage, by training artificial neural network, correction rate of recognition was obtained 73.6%. In order to enhancement in results, we used Mel filter bank. Entropy of each sub-band constitutes elements of next feature vector. By applying Discrete Cosine Transform (DCT) over logarithm of this vector, new feature vector were obtained, we named them MFECs. By MFECs vectors we achieved 88.3% of correction rate. So, MFECs are convenient features to classify cry of infants with hearing disorder from normal infants.
婴儿的哭声是一种多模态行为,它包含了很多关于婴儿的信息,特别是关于婴儿健康的信息。本文提出了婴儿哭声分析的一个新特点,即利用婴儿哭声的Mel频率多波段熵倒谱提取来识别听力障碍婴儿和正常婴儿两类人群。信号处理阶段包括消噪、滤波、预强化和特征提取。对所有样本进行傅里叶变换后,作为单个特征计算谱熵。在分类阶段,通过训练人工神经网络,识别正确率达到73.6%。为了增强结果,我们使用了Mel滤波器组。每个子带的熵构成下一个特征向量的元素。通过对该向量的对数进行离散余弦变换(DCT),得到新的特征向量,我们将其命名为MFECs。MFECs载体的校正率为88.3%。因此,MFECs是区分听力障碍婴儿与正常婴儿哭声的方便特征。
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引用次数: 14
Using survival models to analyze the effects of social attributes on length of stay of stroke patients 运用生存模型分析社会属性对脑卒中患者住院时间的影响
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384062
C. Kwoh, K. Lee, T. Le
Hospital length of stay (LOS) is a widely accepted indicator of hospital activity and performance of clinical care. We have collected and analyzed data on LOS of 4,086 stroke patients discharged from the Singapore General Hospital (SGH) for the duration 2004–2007. We chose to study stroke patients' data because stroke is an important chronic disease which requires significant social support and healthcare resources. We used survival analysis to study the effects of social attributes on LOS, using discharge from hospital as the time to event. Gender, age, ethnicity and subsidy status were studied as covariates. We discovered that old age increases the probability of long stay. Indian race decreases the probability of stay while Other makes the patient stay longer as compared to Chinese. Patients who were not fee-subsidized have lower chances of stay than those who were. Gender and Malay race did not have a significant effect on the stay probability. The effects of ethnicity and paying status on LOS reflect the influences of cultural environment and socioeconomic status. This demonstrates the importance of social determinants on healthcare and their consequent effects on the utilization of healthcare resources.
住院时间(LOS)是一个被广泛接受的医院活动和临床护理表现的指标。我们收集并分析了2004-2007年间从新加坡总医院(SGH)出院的4,086名中风患者的LOS数据。我们选择研究脑卒中患者的数据是因为脑卒中是一种重要的慢性疾病,需要大量的社会支持和医疗资源。我们以出院为事件发生时间,采用生存分析研究社会属性对LOS的影响。性别、年龄、种族和补贴状况作为协变量进行研究。我们发现老年增加了长期停留的可能性。与中国人相比,印度人降低了住院的可能性,而其他人种则使患者住院的时间更长。没有获得费用补贴的患者比获得费用补贴的患者住院的几率要低。性别和马来人种族对居留概率没有显著影响。族裔和薪酬地位对LOS的影响反映了文化环境和社会经济地位的影响。这表明社会决定因素对医疗保健的重要性及其对医疗保健资源利用的后续影响。
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引用次数: 3
In-vitro screening and docking study of fosinopril and its analogs 福辛普利及其类似物的体外筛选与对接研究
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384099
S. Kini, J. Chaudhary, S. Arora
Hypertension is the most common cardiovascular disease. The prevalence of hypertension increases with advancing age; for example, about 50% of people between the ages of 60 and 69 years old have hypertension, and the prevalence is further increased beyond age of 70. Many angiotensin converting enzyme (ACE) inhibitors are known to be useful in the treatment of hypertension.
高血压是最常见的心血管疾病。高血压患病率随着年龄的增长而增加;例如,60岁至69岁的人群中约有50%患有高血压,70岁以上的人群患病率进一步增加。许多血管紧张素转换酶(ACE)抑制剂在高血压的治疗中是有用的。
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引用次数: 0
A new wavelet based algorithm for estimating respiratory motion rate using UWB radar 一种基于小波的超宽带雷达呼吸运动速率估计新算法
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384095
M. Baboli, S. Ghorashi, N. Saniei, A. Ahmadian
UWB signals have become attractive for their particular advantage of having narrow pulse width which makes them suitable for remote sensing of vital signals. In this paper a novel approach to estimate periodic motion rates, using Ultra Wide Band (UWB) signals is proposed. The proposed algorithm which is based on wavelet transform is used as a non-contact tool for measurement of respiration motion rate. Compared with traditional contact measurement devices, experimental results utilizing a 3.2 GHz bandwidth transceiver, demonstrate 99% similar results. The standard deviation of the proposed algorithm for 30 independent experiments has obtained 19% for respiration motion.
超宽带信号以其具有窄脉冲宽度的特殊优势而受到人们的青睐,这使得超宽带信号适用于生命信号的遥感。提出了一种利用超宽带(UWB)信号估计周期运动速率的新方法。提出了一种基于小波变换的非接触式呼吸运动速率测量方法。与传统的接触式测量装置相比,利用3.2 GHz带宽收发器的实验结果相似度达到99%。在30个独立实验中,该算法的呼吸运动标准差为19%。
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引用次数: 33
Non-invasive measurement of blood flow using magnetic disturbance method 利用磁干扰法无创测量血流
Pub Date : 2009-12-01 DOI: 10.1109/ICBPE.2009.5384098
C. T. Phua, Gaelle Lissorgues
Current laser Doppler method of blood flow sensing requires optical contact to the skin, tend to be bulky and have performance subjective to body fluids (e.g. blood, perspiration) and environmental contaminants (e.g. mud, water). This paper proposes a novel method of noninvasive acquisition of blood flow by measuring the magnetic disturbance created due to blood flowing through a localized magnetic field. The proposed system employs a GMR based magnetic sensor and magnet of 3 mm radius, placed on a major blood vessel. The magnetic field generated by the magnet acts both as the biasing field for the sensor and also the uniform magnetic flux for blood flow disturbance. As such, the system is compact, operates at room temperature and is able to sense through clothing. The signal acquired from the magnetic and optical methods are compared using the post-occlusive reactive hyperaemia test, where measurement results on 6 different healthy subjects are found to have error of less than 5%, showing the successful use of the magnetic method to measure blood flow.
目前的激光多普勒血流传感方法需要与皮肤进行光学接触,往往体积庞大,并且对体液(如血液、汗水)和环境污染物(如泥浆、水)的性能也很主观。本文提出了一种通过测量血液流经局部磁场所产生的磁干扰来无创采集血流的新方法。该系统采用基于GMR的磁传感器和半径为3毫米的磁铁,放置在主要血管上。磁体产生的磁场既作为传感器的偏置场,又作为血流干扰的均匀磁通量。因此,该系统结构紧凑,可在室温下工作,并能通过衣服进行感应。利用闭塞后反应性充血试验对磁法和光法获得的信号进行比较,发现6个不同健康受试者的测量结果误差小于5%,表明磁法测量血流的成功使用。
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引用次数: 12
期刊
2009 International Conference on Biomedical and Pharmaceutical Engineering
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