使用词嵌入的无监督学习从COVID-19药物文献中捕获静态知识

Tasnim Gharaibeh, E. Doncker
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引用次数: 1

摘要

随着COVID-19患者涌入世界各地的医院,医生们正在努力寻找有效的抗病毒疗法来挽救生命。然而,目前缺乏针对COVID-19的有效药物。多种COVID-19疫苗试验和治疗正在进行中,但还需要更多的时间和测试。此外,导致COVID-19的SARS-CoV-2病毒在包括狗、猪、鸡和鸭在内的多种动物中复制不良,这限制了临床前动物研究。我们建立了一个无监督深度学习模型(CDVec),使用word2vec从文献中出现的文章语料库中选择性地关注COVID-19候选药物产生词嵌入,以确定可能用于COVID-19治疗的有希望的靶标药物。
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Unsupervised Learning with Word Embeddings Captures Quiescent Knowledge from COVID-19 Drugs Literature
As COVID-19 patients flood hospitals worldwide, physicians are trying to search for effective antiviral therapies to save lives. However, there is currently a lack of proven effective medications against COVID-19. Multiple COVID-19 vaccine trials and treatments are underway, but yet need more time and testing. Furthermore, the SARS-CoV-2 virus that causes COVID-19 replicates poorly in multiple animals, including dogs, pigs, chickens, and ducks, which limits preclinical animal studies. We built an unsupervised deep learning model (CDVec) to produce word-embeddings using word2vec from a corpus of articles selectively focusing on COVID-19 candidate drugs that appeared in the literature to identify promising target drugs that could be used in COVID-19 treatment.
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