妊娠奶牛生殖道支原体病抗生素治疗对阴道分泌物细胞学和免疫学特性的影响

R. Vasiliev
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摘要

目的:研究大环内酯类抗生素土曲霉素的治疗效果及其对阴道分泌物免疫学和细胞学特征的影响。材料和方法。试验分为2组,每组8只。第一组为无阴道炎临床症状的奶牛,支原体PCR检测阳性;第二组是临床健康的奶牛,对支原体进行阴性PCR检测。第一组奶牛是治疗生殖器支原体病的奶牛,在预期分娩前40天皮下注射抗生素traksovet 100(图拉霉素),剂量为每千克动物体重2.5毫克。采集两组奶牛阴道分泌物,测定Ig G、Ig M、Ig A、sIg A含量、溶菌酶活性及阴道涂片细胞学检查结果。在生殖道支原体病奶牛中使用土曲霉素后,阴道分泌物中Ig M和sIg a含量下降,达到健康动物的指标值。阴道分泌物溶菌酶的活性虽然显著增加,但仍低于健康奶牛。在抗生素治疗的背景下,阴道涂片细胞学检查显示上皮细胞和白细胞数量明显减少。使用traksovet 100抗生素治疗患有生殖器支原体病的奶牛,75%的患病动物阴道粘膜的病原体被消除,阴道分泌物的细胞学和免疫学特征得到部分恢复。
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Effect of antibiotic therapy of genital mycoplasmosis in pregnant cows on cytological and immunological characteristics of vaginal secretions
Purpose: the aim is to study the therapeutic efficacy of the macrolide group antibiotic tulatromycin and its effect on the immunological and cytological characteristics of vaginal secretions.Materials and methods. For the experiment, 2 groups of 8 animals each were formed. The first group - cows without clinical signs of vaginitis with a positive PCR test for Mycoplasma spp.; the second group - clinically healthy cows with a negative PCR test for Mycoplasma spp. The first group of cows, the group for the treatment of genital mycoplasmosis, used the antibiotic traksovet 100 (tulatromycin) at a dose of 2.5 mg per 1 kg of animal body weight, subcutaneously, once 40 days before the expected delivery. Vaginal secretions were collected from both groups of cows, in which the content of Ig G, Ig M, Ig A, sIg A, lysozyme activity and cytological examination of the vaginal smear were determined.Results. The use of tulatromycin in cows with genital mycoplasmosis leads to a decrease in the content of Ig M and sIg A in vaginal secretions, which reach the values of these indicators in healthy animals. A less pronounced positive effect is observed with respect to the activity of the vaginal secretion lysozyme, which, although significantly increased, remains lower than in healthy cows. Cytological examination of vaginal smears against the background of antibiotic therapy showed a significant decrease in the number of epithelium and leukocytes.Conclusion. The use of traksovet 100 antibiotic as etiotropic therapy for cows with genital mycoplasmosis leads to the elimination of the pathogen from the vaginal mucosa in 75 % of sick animals and provides partial restoration of cytological and immunological characteristics of vaginal secretions.
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