碳酸锂对人类生理周期的影响。

A Johnsson, B Pflug, W Engelmann, W Klemke
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引用次数: 53

摘要

五组两名志愿者在北极夏季条件下(斯匹次卑尔根岛)与世隔绝的小木屋里生活了四周,没有时间信息。他们分别服用碳酸锂或安慰剂。所有动物的昼夜温度和活动/休息节律均自由运行,周期超过24小时。碳酸锂作用下,可以表现出周期延长效应。这有助于理解锂盐对躁狂抑郁发作的预防作用。
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Effect of lithium carbonate on circadian periodicity in humans.

Five groups of two volunteers lived during four weeks under arctic summer conditions (Spitsbergen) isolated in huts, without time information. They received lithium carbonate or placebo. All showed free-run of their circadian temperature and activity/rest rhythms with periods longer than 24 hours. Under lithium carbonate, a period-lengthening effect can be shown. This could help to understand theprophylactic effect of lithium salts in manic-depressive episodes.

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