[The significance of the degree of circulatory disorders in hematologic findings and organ injuries in neonates and infants].

The paper describes various forms of shock which arise in pediatric casuistics as well as pathophysiological changes by which these states are accompanied. The main changes take place in microcirculation. The level and the volume of the lesion of cellular tissue structures depend on the athiology, duration and intensity of noxae. The paper gives clinical haemathological and coagulational parameters necessary to a physician for the evaluation of the state of shock of the diseased. It further points out the meaning of intensity of disturbances within circulation, their dependence and repercutions on haemodynamic, haemothological and coagulational findings, especially in early infancy. To enable the application of quick and afficient therapy upon which the result of treatment depends, the papern deals in detail with development of DIC during the Itates of shock, with importance of wound and of quick and precise laborathory detection and differential diagnostics, and with the circumstances which make these phenomena difficult in early infancy. In the treatment of DIC priority is given to intravenous application of AT-III complex human, concentrated and purified, activated in vitro with heparin. Finally there is a description of examinations of pathological-anatomical-hysthological findings of obduced new-borns and infants ill with irreversible shock accompanied by DIC, whose organs show some particular features in relation to adults.