G R Pettit, C L Herald, G F Judd, G Bolliger, L D Vanell, E Lehto, C P Pase
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引用次数: 0
摘要
沙漠万寿菊。和grey (Compositae)已被发现产生一系列倍半萜素，显著抑制小鼠淋巴细胞白血病P388及其体外细胞系的生长。通过生物测定分离分离得到baileyin(1)、fastigilins B和C (3a和2a)、radiatin (3b)、pleniradin (4a)和新的pseudoguaianolide multiradiatin (2b)。fastigilin C (2a)和放疗(3b)显示出最显著的抗肿瘤活性。
The desert-marigold Baileya multiradiata Harv. and Gray (Compositae) has been found to produce a series of sesquiterpenes that markedly inhibit growth of the murine lymphocytic leukemia P388 and the corresponding in vitro cell line. Separation guided by bioassay led to the isolation of baileyin (1), fastigilins B and C (3a and 2a), radiatin (3b), pleniradin (4a), and the new pseudoguaianolide multiradiatin (2b). The most significant antitumor activity was displayed by fastigilin C (2a) and radiation (3b).
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