不同化学种类钒在大鼠体内代谢模式的相似性

E. Sabbioni, E. Marafante, L. Amantini, L. Ubertalli, C. Birattari
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引用次数: 56

摘要

为了了解钒的氧化状态对其代谢行为的影响,制备了不同的48v标记的钒化合物,如阳离子VO2+(V)、VO2+(IV)、V3+(III)和阴离子V4O123−(V)、VS43−(V),并静脉注射到大鼠体内。在全组织以及肝脏和肾脏匀浆的细胞核、线粒体、溶酶体、微粒体和细胞质中测量48V放射性。利用{48}v标记等离子体的凝胶过滤研究了48V放射性在等离子体组分之间的分布。研究结果表明,不同化学形式的钒在动物体内有共同的途径。相似之处在于其在不同组织中的分布及其在细胞内的分布,以及在血液中的转运,其中48V均存在于与转铁蛋白结合的血浆中。所得结果倾向于排除钒的氧化状态对其代谢的可能影响,并支持体内存在两种机制将不同化学形式的钒离子转化为具有相同价态的钒离子。
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Similarity in metabolic patterns of different chemical species of vanadium in the rat

To gain information about the influence of the oxidation state of vanadium on its metabolic behavior, different 48V-labelled vanadium compounds, such as cationic VO2+(V), VO2+(IV), V3+(III), and anionic V4O123−(V), VS43−(V) species were prepared and intravenously injected into rats. The 48V radioactivity was measured in whole tissues as well as in nuclei, mitochondria, lysosomes, microsomes, and cytosols from liver and kidney homogenates. The distribution of 48V redioactivity between the plasma components was investigated using gel filtration of the {48}V-labeled plasma. The findings indicate that there are common pathways of the different chemical forms of vanadium in animals. The similarities are referred to the distribution in different tissues and their intracellular distribution as well as to the transport in the blood, in which 48V was always found in the plasma bound to transferrin. The results obtained tend to exclude a possible influence of the oxidation state of vanadium on its metabolism and support the existence in the body of two mechanisms of conversion of different chemical forms of vanadium ions to one with the same valence.

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