{"title":"脉冲电场对单个心脏细胞收缩力的梯度效应","authors":"M. R. Mulligan, R. O'Neill, P. Zei, L. Tung","doi":"10.1109/IEMBS.1988.95240","DOIUrl":null,"url":null,"abstract":"The effects of high-intensity electric fields on excitability and contractility of the heart at the cellular level are pertinent to defibrillation and electrical ablation. Stimulation of single cardiac cells with a rectangular pulsed electric field elicits twitch contraction. Variation of the stimulus intensity and duration shows a distinct strength-duration curve for the threshold of excitation, T1. T1 is mediated by the cell orientation with respect to the electric field (parallel or perpendicular). Above the threshold level is a second threshold level, T2, for cellular contracture. T2 has a shape similar to that of T1, and may be a consequence of formation of pores in the cell membrane (electroporation).<<ETX>>","PeriodicalId":227170,"journal":{"name":"Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1988-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"12","resultStr":"{\"title\":\"Graded effects of pulsed electric fields on contractility of single heart cells\",\"authors\":\"M. R. Mulligan, R. O'Neill, P. Zei, L. Tung\",\"doi\":\"10.1109/IEMBS.1988.95240\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effects of high-intensity electric fields on excitability and contractility of the heart at the cellular level are pertinent to defibrillation and electrical ablation. Stimulation of single cardiac cells with a rectangular pulsed electric field elicits twitch contraction. Variation of the stimulus intensity and duration shows a distinct strength-duration curve for the threshold of excitation, T1. T1 is mediated by the cell orientation with respect to the electric field (parallel or perpendicular). Above the threshold level is a second threshold level, T2, for cellular contracture. T2 has a shape similar to that of T1, and may be a consequence of formation of pores in the cell membrane (electroporation).<<ETX>>\",\"PeriodicalId\":227170,\"journal\":{\"name\":\"Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1988-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"12\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1109/IEMBS.1988.95240\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/IEMBS.1988.95240","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Graded effects of pulsed electric fields on contractility of single heart cells
The effects of high-intensity electric fields on excitability and contractility of the heart at the cellular level are pertinent to defibrillation and electrical ablation. Stimulation of single cardiac cells with a rectangular pulsed electric field elicits twitch contraction. Variation of the stimulus intensity and duration shows a distinct strength-duration curve for the threshold of excitation, T1. T1 is mediated by the cell orientation with respect to the electric field (parallel or perpendicular). Above the threshold level is a second threshold level, T2, for cellular contracture. T2 has a shape similar to that of T1, and may be a consequence of formation of pores in the cell membrane (electroporation).<>
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