Acute and Chronic Effects of Physical Activity on Emerging Risk Factors of Heart Attack in Overweight Men

Background: Homocysteine, fibrinogen and C-reactive protein (CRP) are three independent factors that independently and strongly predict the cardiovascular risks. Objectives: Thepurposeof thisstudywastoevaluatetheacuteandchronicresponsesof thesecardiovascularriskfactorsfollowing physical activity in overweight healthy inactive middle-aged men. Methods: Thesubjectsincluded21healthyinactivementhatwereassignedintotwogroupsof experimental(N=11)andcontrol(N = 10). The exercise protocol consisted of circuit resistance exercise (one session protocol) with intensity of 35% of 1RM; endurance training protocol lasting for 12 weeks (three sessions a week) and running exercise with intensity of 75% to 85% of maximum heart rate. Bloodsamplingsweretakeninpretestandposttest. Thedatawasusedusingpairedandindependentsamples t -testwereused for statistical analysis of data. Results: TheresultsindicatedthattherewasasignificantincreaseinhomocysteineandCRPfollowingcircuitresistanceexercise(P ≤ 0.05)whilenosignificantchangewasfoundinfibrinogeninexperimentalgroupafterexercise(P> 0.05). Additionally,thelevels of CRP and homocysteine were significantly decreased after three months of aerobic exercises, (P ≤ 0.05) however no significant change of fibrinogen was observed (P > 0.05). Conclusions: Althoughitseemsthatatherogenicinflammatoryprocessesaremoresensitivetoexercisethancoagulatoryprocesses in inactive middle-aged men, more researches are needed for crucial decisions.