红细胞-粒细胞花环。在某些自身免疫性溶血性贫血病例中发现的免疫细胞相互作用。

A M Marmont, M Raffo
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引用次数: 0

摘要

在两例自身免疫性溶血性贫血的毛细血管血液中发现红细胞-粒细胞玫瑰花结(EGR),第一例由IgM非i抗体引起,第二例由IgG引起。两种抗体均激活补体,C3b在红细胞上被证实。莲座表现为6-10个红细胞粘附在一个中央粒细胞上的排列;吞噬作用最普遍不存在。在某些自身免疫性溶血性贫血病例中,在毛细血管血液中发现EGR可能有助于识别补体活化直至C3b阶段。
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The erythrocyte-granulocyte rosette. An immune cellular interaction found in some cases of autoimmune hemolytic anemias.

Erythrocyte-granulocyte rosettes (EGR) were found in the capillary blood of two cases of autoimmune haemolytic anemia, the first caused by an IgM non-I antibody and the second by an IgG. Both antibodies activated complement, and C3b was demonstrated on the erythrocytes. The rosettes appeared as arrangements of 6-10 red cells adhering to a central granulocyte; phagocytosis was most generally absent. The finding of EGR in the capillary blood may be useful for the recognition of complement activation up to the C3b stage in some cases of autoimmune haemolytic anemia.

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