哺乳动物颅骨分子逆流转移研究综述

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引用次数: 0

摘要

在哺乳动物物种中,已经确定了分子运输和逆流转移的各种头部部位,包括脉络膜丛血-脑脊液屏障(CPB-CFB)、海绵窦-颈动脉网复合体以及鼻血管交换途径。目前的文献综述已经进行,以纳入文章强调的主要发现,结论和预期的影响的研究,旨在阐明大脑中的逆流传递过程。虽然生物活性物质的分子逆流转运的头侧位点已经被明确定义,并且它们对神经稳态调节和生殖生理学的不可否认的重要性已经得到承认,但最近报道的缺乏使人们对在不久的将来这些位点将被充分利用其治疗潜力的乐观情绪有所减弱。
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A Scoping Review of Research on the Cranial Molecular Counter-Current Transfer in Mammals
Various cephalic sites of the molecular transport and counter-current transfer have been identified in mammalian species, including the choroid plexus blood-cerebrospinal fluid barrier (CPB-CFB), the cavernous sinus-carotid rete complex as well as the nasal vasculature exchange pathway. The present literature review has been conducted to incorporate articles highlighting the key findings, conclusions, and the anticipated impact of studies aimed to elucidate the counter-current transfer processes in the brain. Although cephalic sites of the molecular counter-current transport of biologically active substances have been clearly defined and their undeniable importance for neurohomeostatic regulations and reproductive physiology has been recognized, a scarcity of most recent reports have slightly dampened the optimism that in the nearest future these sites will be exploited to their full therapeutic potential.
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