分子生物学和戴维-法拉第研究实验室在其诞生中所起的关键作用

John Meurig Thomas
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摘要

20世纪20年代末、30年代初,正是在戴维·法拉第研究实验室,威廉·布拉格爵士的一群学生(尤其是j·d·伯纳尔和w·t·阿斯特伯里)开始用x射线方法研究活分子的所有性质,比如皮肤、氨基酸、类固醇、指甲、蛋白质、肌腱和病毒。伯纳尔回到剑桥,阿斯特伯里在利兹大学成立了一个分子生物物理学小组,这些研究仍在继续。多萝西·霍奇金(来自牛津)和马克斯·佩鲁茨(来自维也纳)都加入了剑桥的伯纳尔,他们在确定“活”分子的结构方面取得了巨大进展。霍奇金阐明了胆固醇和许多其他类固醇的结构。Perutz在剑桥开始了他关于血红蛋白的不朽研究,他也在DFRL研究过它。
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Molecular Biology and the Crucial Role Played by the Davy–Faraday Research Laboratory in its Birth
It was at the Davy Faraday Research Laboratory in the late 1920s, early 1930s, that a group of Sir William Bragg’s research students (notably J. D. Bernal and W. T. Astbury) started to study, by X-ray methods, all nature of living molecules, such as skin, amino acids, steroids, finger nails, proteins, tendons and viruses. These studies continued when Bernal returned to Cambridge and Astbury started a molecular biophysics group in the University of Leeds. Dorothy Hodgkin (from Oxford) and Max Perutz (from Vienna) both joined Bernal at Cambridge, and they made enormous progress in determining the structures of ‘living’ molecules. Hodgkin elucidated the structure of cholesterol and many other steroids. And Perutz started his monumental work on haemoglobin at Cambridge, and he also studied it at the DFRL.
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