使用头孢吡肟/舒巴坦治疗碳青霉烯耐药细菌引起的感染

A. N. Koshmanova, M. Maksimov
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引用次数: 0

摘要

头孢吡肟/舒巴坦是一种具有广谱抗菌活性的联合抗生素,包括头孢吡肟(第四代头孢菌素)和舒巴坦(β -内酰胺酶抑制剂),比例为1:1。头孢吡肟/舒巴坦具有杀菌作用:由于阻断转肽酶,导致细胞壁合成紊乱,肽聚糖交联形成紊乱[1]。今天,抗生素耐药性问题正在迅速发展。在世卫组织的清单中,由产esbl的革兰氏阴性菌(对头孢菌素耐药)以及耐碳青霉烯肠杆菌、鲍曼不动杆菌和铜绿假单胞菌引起的感染占据了开发新抗生素的高度优先级别[2]。多重耐药菌引起的感染病程较长,住院时间较长,现代抗菌药物难以治疗,死亡风险增加[3]。在这方面,深入研究单个抗菌药物的作用及其与β-内酰胺酶抑制剂在治疗多重耐药微生物引起的疾病中的作用至关重要。
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Use of cefepime/sulbactam in the treatment of infections caused by carbapenem-resistant bacteria
Cefepime/sulbactam is a combined antibiotic with a wide spectrum of antimicrobial activity, including cefepime, the fourth-generation cephalosporin, and sulbactam, the beta-lactamase inhibitor, in a 1:1 ratio. Cefepime/sulbactam has a bactericidal effect: it causes a disorder in cell wall synthesis due to blockade of transpeptidase and a disorder in the formation of cross-links in peptidoglycan [1]. Today, the problem of antibiotic resistance is growing rapidly. In the WHO list, a critically high level of priority for the development of new antibiotics is occupied by infections caused by ESBL-producing gram-negative bacteria that are resistant to cephalosporins, as well as carbapenem-resistant Enterobacterales, Acinetobacter baumannii and Pseudomonas aeruginosa [2]. Infections caused by multiresistant bacteria are characterized by a longer course, require prolonged hospitalization, are very difficult to treat with modern antibacterial drugs, and increase the risk of death [3]. In this regard, a deeper study of the action of individual antibacterial drugs and their combination with β-lactamase inhibitors in the treatment of diseases caused by multiresistant microorganisms is crucial.
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