绿桉叶水提物的急性毒性、抗氧化和抗菌活性评价

Ouattara Monique Brigitte, M. Kiendrebeogo, O. Nacoulma
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摘要

本研究的目的是通过科学研究来评价布基纳法索传统医学中使用的camaldulensis治疗疟疾的潜力。然后对其急性一般毒性、抗氧化和抗菌活性进行了评价。在布基纳法索,camaldulensis Dehnhardt(桃金树科)的叶子被用于治疗疟疾和呼吸系统疾病。叶子的水提取物是传统治疗师推荐的使用形式。我们研究了在布基纳法索广泛使用的桉树叶水提取物的急性毒性、抗氧化活性、抗菌活性和植物化学成分。研究了NMRI品系小鼠的急性毒性。在最大剂量为2000 mg/kg体重时,水提物无毒性。提取物具有抗氧化活性,ic50为12.5 μ g/mL。提取物对大肠杆菌、铜绿假单胞菌和金黄色葡萄球菌三种细菌均无活性。我们已经确定的植物化学化合物有生物碱、类黄酮、单宁和酚类化合物、三萜和类固醇、皂苷。
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Evaluation of Acute Toxicity, Antioxidant and Antibacterial Activities of Aqueous Extracts of Leaves of Eucalyptus camaldulensis Dehnhardt (MYRTACEAE) Synonym: Eucalyptus rostrata Schelcht
The aim of this study is to evaluate by scientific studies, the Eucalyptus camaldulensis potentialities used in traditional medicine in Burkina Faso to treat malaria. Then, acute general toxicity, antioxidant and antibacterial activities phytochemical composition were evaluated. The leaves of Eucalyptus camaldulensis Dehnhardt (Myrtaceae) are used in Burkina Faso for the treatment of malaria and respiratory diseases. Aqueous extracts of the leaves are the form of use recommended by traditional healers. We studied the acute toxicity antioxidant activity, the antibacterial activity, the phytochemical composition of aqueous extracts of Eucalyptus camaldulensis , used everywhere in Burkina Faso. Acute toxicity was studied in NMRI strain mice. The aqueous extracts were not toxic at the maximum dose of 2000 mg/kg body weight. The extracts presented antioxidant activity with an IC 50 which is 12.5 &mug/mL. The extracts showed no bacterial activity on three strains of bacteria tested: Escherichia coli , Pseudomonas aeruginosa and Staphylococcus aureus . Phytochemicals compounds that we have identified are alkaloids, flavonoids, tannins and phenolics compounds, triterpenoids and steroids, saponosides.
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